biostudies-literatureHaslinger CAustrian Science Fund FWF459-471https://www.ebi.ac.uk/biostudies/studies/S-EPMC10113345biostudies-literatureUnknown154(5)Herein, we present a new route to synthesize poly(2-oxazoline)s (POx) with coumarin moieties as pendant groups that can be crosslinked by irradiation to form hydrogels. The synthesis of a novel coumarin-containing 2-oxazoline monomer, 2-[(4-methyl-7-coumarinyloxy)methyl]oxazoline is described in four steps and further its subsequent homo- and copolymerization with 2-ethyl-2-oxazoline (EtOx) via cationic ring-opening polymerization (CROP). The received polymers with different coumarin content (8, 4 and 2 mol%) were compared with a known copolymer synthesized via postpolymerization modification of partially hydrolyzed poly(2-ethyl-2-oxazoline) (PEtOx) with a coumarin derivative. The thermoresponsive behavior of the POx in aqueous solutions was investigated, showing a clear difference in the Monatshefte fur chemieSynthesis of coumarin-containing poly(2-oxazoline)s and light-induced crosslinking for hydrogel formation.PMC10113345M 2805Haslinger CZahoranova ABaudis SfalseSynthesis of coumarin-containing poly(2-oxazoline)s and light-induced crosslinking for hydrogel formation.Herein, we present a new route to synthesize poly(2-oxazoline)s (POx) with coumarin moieties as pendant groups that can be crosslinked by irradiation to form hydrogels. The synthesis of a novel coumarin-containing 2-oxazoline monomer, 2-[(4-methyl-7-coumarinyloxy)methyl]oxazoline is described in four steps and further its subsequent homo- and copolymerization with 2-ethyl-2-oxazoline (EtOx) via cationic ring-opening polymerization (CROP). The received polymers with different coumarin content (8, 4 and 2 mol%) were compared with a known copolymer synthesized via postpolymerization modification of partially hydrolyzed poly(2-ethyl-2-oxazoline) (PEtOx) with a coumarin derivative. The thermoresponsive behavior of the POx in aqueous solutions was investigated, showing a clear difference in the 2023-01-01T00:00:00Z20232025-04-22T01:38:31.529Z2025-04-05T20:05:40.707ZS-EPMC101133453709135510.1007/s00706-022-03013-8