{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Blaya D"],"funding":["National Institute on Alcohol Abuse and Alcoholism","Instituto de Salud Carlos III","NIDDK NIH HHS","NIAAA NIH HHS","Ministerio de Educación, Cultura y Deporte","ERAB: The European Foundation for Alcohol Research"],"pagination":["1006-1017"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10113804"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(4)"],"pubmed_abstract":["<h4>Objectives</h4>Alcoholic hepatitis (AH) is a severe condition characterized by a marked inflammatory response and high short-term mortality. Endothelial dysfunction (ED) is an early event in vascular and inflammatory disorders. The aim of this study is to evaluate ED in AH patients.<h4>Methods</h4>Prognostic value of ED biomarkers was evaluated in patients with severe AH (n = 67), compensated alcoholic cirrhosis (n = 15), heavy drinkers without liver disease (n = 15) and controls (n = 9), and in a validation cohort of 50 patients with AH. Gene expression of ED markers was analyzed in liver tissue.<h4>Results</h4>Plasma levels of ED markers such as vascular cell adhesion molecule 1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1), E-selectin and von Willebrand factor (vWF) increased"],"journal":["Hepatology international"],"pubmed_title":["Endothelial dysfunction markers predict short-term mortality in patients with severe alcoholic hepatitis."],"pmcid":["PMC10113804"],"funding_grant_id":["P30 DK120531","FIS PI12/01265","CPII16/00041","U01 AA026972","FIS PI17/00673","PI20/00765","EA1653","1U01AA021908","U01 AA021908","FPU","1U01AA021908-01-33490"],"pubmed_authors":["Tanguy M","Altamirano J","Pose E","Bataller R","Sancho-Bru P","Rubio-Tomas T","Argemi J","Issoufaly T","Caballeria J","Lozano J","Morales-Ibanez O","Blaya D","Rodrigo-Torres D","Affo S","Gratacos-Gines J","Coll M","Rautou PE"],"additional_accession":[]},"is_claimable":false,"name":"Endothelial dysfunction markers predict short-term mortality in patients with severe alcoholic hepatitis.","description":"<h4>Objectives</h4>Alcoholic hepatitis (AH) is a severe condition characterized by a marked inflammatory response and high short-term mortality. Endothelial dysfunction (ED) is an early event in vascular and inflammatory disorders. The aim of this study is to evaluate ED in AH patients.<h4>Methods</h4>Prognostic value of ED biomarkers was evaluated in patients with severe AH (n = 67), compensated alcoholic cirrhosis (n = 15), heavy drinkers without liver disease (n = 15) and controls (n = 9), and in a validation cohort of 50 patients with AH. Gene expression of ED markers was analyzed in liver tissue.<h4>Results</h4>Plasma levels of ED markers such as vascular cell adhesion molecule 1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1), E-selectin and von Willebrand factor (vWF) increased","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Aug","modification":"2025-04-04T00:03:46.213Z","creation":"2025-04-04T00:03:46.213Z"},"accession":"S-EPMC10113804","cross_references":{"pubmed":["33954832"],"doi":["10.1007/s12072-021-10165-y"]}}