biostudies-literatureBlaya DNational Institute on Alcohol Abuse and AlcoholismInstituto de Salud Carlos IIINIDDK NIH HHSNIAAA NIH HHSMinisterio de Educación, Cultura y DeporteERAB: The European Foundation for Alcohol Research1006-1017https://www.ebi.ac.uk/biostudies/studies/S-EPMC10113804biostudies-literatureUnknown15(4)<h4>Objectives</h4>Alcoholic hepatitis (AH) is a severe condition characterized by a marked inflammatory response and high short-term mortality. Endothelial dysfunction (ED) is an early event in vascular and inflammatory disorders. The aim of this study is to evaluate ED in AH patients.<h4>Methods</h4>Prognostic value of ED biomarkers was evaluated in patients with severe AH (n = 67), compensated alcoholic cirrhosis (n = 15), heavy drinkers without liver disease (n = 15) and controls (n = 9), and in a validation cohort of 50 patients with AH. Gene expression of ED markers was analyzed in liver tissue.<h4>Results</h4>Plasma levels of ED markers such as vascular cell adhesion molecule 1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1), E-selectin and von Willebrand factor (vWF) increasedHepatology internationalEndothelial dysfunction markers predict short-term mortality in patients with severe alcoholic hepatitis.PMC10113804P30 DK120531FIS PI12/01265CPII16/00041U01 AA026972FIS PI17/00673PI20/00765EA16531U01AA021908U01 AA021908FPU1U01AA021908-01-33490Tanguy MAltamirano JPose EBataller RSancho-Bru PRubio-Tomas TArgemi JIssoufaly TCaballeria JLozano JMorales-Ibanez OBlaya DRodrigo-Torres DAffo SGratacos-Gines JColl MRautou PEfalseEndothelial dysfunction markers predict short-term mortality in patients with severe alcoholic hepatitis.<h4>Objectives</h4>Alcoholic hepatitis (AH) is a severe condition characterized by a marked inflammatory response and high short-term mortality. Endothelial dysfunction (ED) is an early event in vascular and inflammatory disorders. The aim of this study is to evaluate ED in AH patients.<h4>Methods</h4>Prognostic value of ED biomarkers was evaluated in patients with severe AH (n = 67), compensated alcoholic cirrhosis (n = 15), heavy drinkers without liver disease (n = 15) and controls (n = 9), and in a validation cohort of 50 patients with AH. Gene expression of ED markers was analyzed in liver tissue.<h4>Results</h4>Plasma levels of ED markers such as vascular cell adhesion molecule 1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1), E-selectin and von Willebrand factor (vWF) increased2021-01-01T00:00:00Z2021 Aug2025-04-04T00:03:46.213Z2025-04-04T00:03:46.213ZS-EPMC101138043395483210.1007/s12072-021-10165-y