{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(2)"],"submitter":["Prakash A"],"pubmed_abstract":["Among the HPV-mediated cervical cancers, cellular factor BRN3A has gained considerable attention due to its role in promoting an anti-apoptotic cellular environment and in facilitating epitheliotropic transformations of the host. The majority of previous studies looked at BRN3A's molecular characteristics; however, the possibility of genetic variations in BRN3A's auto-regulatory region in relation to cervical cancer risk has been underestimated until now. In a retrospective study in the Eastern UP population, India, we detected genetic variations in the cis-regulatory proximal enhancer region located around 5.6 kb upstream of transcription start site of <i>BRN3A</i>. Our analysis of PCR and DNA sequencing confirmed this novel SNP (<i>BRN3A</i> g.60163379A>G) within the auto-regulatory regi"],"journal":["International journal of molecular and cellular medicine"],"pagination":["88-103"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10116355"],"repository":["biostudies-literature"],"pubmed_title":["Novel Variant Identified in the Enhancer Region of Host Transcription Factor, BRN3A, is a Significant Risk Factor for HPV-Induced Uterine Cervix Cancer."],"pmcid":["PMC10116355"],"pubmed_authors":["Srivastava S","Prakash A","Das Purkayastha BP","Roy JK","Aggarwal DD","Ali A","Chaturvedi S"],"additional_accession":[]},"is_claimable":false,"name":"Novel Variant Identified in the Enhancer Region of Host Transcription Factor, BRN3A, is a Significant Risk Factor for HPV-Induced Uterine Cervix Cancer.","description":"Among the HPV-mediated cervical cancers, cellular factor BRN3A has gained considerable attention due to its role in promoting an anti-apoptotic cellular environment and in facilitating epitheliotropic transformations of the host. The majority of previous studies looked at BRN3A's molecular characteristics; however, the possibility of genetic variations in BRN3A's auto-regulatory region in relation to cervical cancer risk has been underestimated until now. In a retrospective study in the Eastern UP population, India, we detected genetic variations in the cis-regulatory proximal enhancer region located around 5.6 kb upstream of transcription start site of <i>BRN3A</i>. Our analysis of PCR and DNA sequencing confirmed this novel SNP (<i>BRN3A</i> g.60163379A>G) within the auto-regulatory regi","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-25T20:11:27.4Z","creation":"2025-04-06T08:18:22.334Z"},"accession":"S-EPMC10116355","cross_references":{"pubmed":["37091039"],"doi":["10.22088/IJMCM.BUMS.11.2.88"]}}