biostudies-literatureUnknown11(2)Prakash AAmong the HPV-mediated cervical cancers, cellular factor BRN3A has gained considerable attention due to its role in promoting an anti-apoptotic cellular environment and in facilitating epitheliotropic transformations of the host. The majority of previous studies looked at BRN3A's molecular characteristics; however, the possibility of genetic variations in BRN3A's auto-regulatory region in relation to cervical cancer risk has been underestimated until now. In a retrospective study in the Eastern UP population, India, we detected genetic variations in the cis-regulatory proximal enhancer region located around 5.6 kb upstream of transcription start site of <i>BRN3A</i>. Our analysis of PCR and DNA sequencing confirmed this novel SNP (<i>BRN3A</i> g.60163379A>G) within the auto-regulatory regiInternational journal of molecular and cellular medicine88-103https://www.ebi.ac.uk/biostudies/studies/S-EPMC10116355biostudies-literatureNovel Variant Identified in the Enhancer Region of Host Transcription Factor, BRN3A, is a Significant Risk Factor for HPV-Induced Uterine Cervix Cancer.PMC10116355Srivastava SPrakash ADas Purkayastha BPRoy JKAggarwal DDAli AChaturvedi SfalseNovel Variant Identified in the Enhancer Region of Host Transcription Factor, BRN3A, is a Significant Risk Factor for HPV-Induced Uterine Cervix Cancer.Among the HPV-mediated cervical cancers, cellular factor BRN3A has gained considerable attention due to its role in promoting an anti-apoptotic cellular environment and in facilitating epitheliotropic transformations of the host. The majority of previous studies looked at BRN3A's molecular characteristics; however, the possibility of genetic variations in BRN3A's auto-regulatory region in relation to cervical cancer risk has been underestimated until now. In a retrospective study in the Eastern UP population, India, we detected genetic variations in the cis-regulatory proximal enhancer region located around 5.6 kb upstream of transcription start site of <i>BRN3A</i>. Our analysis of PCR and DNA sequencing confirmed this novel SNP (<i>BRN3A</i> g.60163379A>G) within the auto-regulatory regi2022-01-01T00:00:00Z20222025-04-25T20:11:27.4Z2025-04-06T08:18:22.334ZS-EPMC101163553709103910.22088/IJMCM.BUMS.11.2.88