{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14"],"submitter":["Cao M"],"pubmed_abstract":["<b>Background:</b> Dyslipidemia is an independent predictor of ischemic stroke (IS). Genetic variations in lipid-metabolism related genes may increase the risk of IS. Fatty acid-binding protein 1 (FABP1) and fatty acid-binding protein 2 (FABP2) are lipid chaperones responsible for lipid transport and metabolism. The present study aimed to determine the association between <i>FABP1</i> or <i>FABP2</i> and ischemic stroke. <b>Methods:</b> A total of 251 participants were recruited composed of 138 patients with ischemic stroke and 113 healthy subjects. DNA was extracted from peripheral blood samples. The rs2241883 polymorphism in <i>FABP1</i> and rs1799883 polymorphism in <i>FABP2</i> were genotyped using polymerase chain reaction-restriction fragment length polymorphism. Generalized multifactor dimensionality reduction (GMDR) was used to find out the interaction combinations between two SNPs and environmental factors. <b>Results:</b> The GA genotype of FABP2 rs1799883 increased susceptibility to ischemic stroke under overdominant inheritance model (<i>p</i> = 0.042). After adjusting for the risk factors of IS, it was associated with a significantly higher risk of IS in the codominant inheritance model (adjust OR = 3.431, 95%CI = 1.060-11.103, <i>p</i> = 0.04). The interactions of <i>FABP1</i> rs2241883 and <i>FABP2</i> rs1799883 were not associated with IS risk (<i>p</i> = 0.172). Moreover, interaction analysis of two genes (rs1799883 and rs2241883) and two environmental factors (smoking and alcohol consumption) was associated with an increased risk of IS (<i>p</i> = 0.011). <b>Conclusion:</b> The GA genotype of FABP2 rs1799883, interactions between rs1799883, rs2241883 and smoking and alcohol consumption were associated with IS risk in Chinese Han populations."],"journal":["Frontiers in genetics"],"pagination":["1056186"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10117902"],"repository":["biostudies-literature"],"pubmed_title":["Polymorphism in genes encoding two fatty acid binding proteins increases risk of ischemic stroke in a Chinese Han population."],"pmcid":["PMC10117902"],"pubmed_authors":["Gong F","Li X","Cao M","Yang L","Zhang Y","Zhou C","Zhang X","Liu B","Zhong J","Fang L","Chen D"],"additional_accession":[]},"is_claimable":false,"name":"Polymorphism in genes encoding two fatty acid binding proteins increases risk of ischemic stroke in a Chinese Han population.","description":"<b>Background:</b> Dyslipidemia is an independent predictor of ischemic stroke (IS). Genetic variations in lipid-metabolism related genes may increase the risk of IS. Fatty acid-binding protein 1 (FABP1) and fatty acid-binding protein 2 (FABP2) are lipid chaperones responsible for lipid transport and metabolism. The present study aimed to determine the association between <i>FABP1</i> or <i>FABP2</i> and ischemic stroke. <b>Methods:</b> A total of 251 participants were recruited composed of 138 patients with ischemic stroke and 113 healthy subjects. DNA was extracted from peripheral blood samples. The rs2241883 polymorphism in <i>FABP1</i> and rs1799883 polymorphism in <i>FABP2</i> were genotyped using polymerase chain reaction-restriction fragment length polymorphism. Generalized multifactor dimensionality reduction (GMDR) was used to find out the interaction combinations between two SNPs and environmental factors. <b>Results:</b> The GA genotype of FABP2 rs1799883 increased susceptibility to ischemic stroke under overdominant inheritance model (<i>p</i> = 0.042). After adjusting for the risk factors of IS, it was associated with a significantly higher risk of IS in the codominant inheritance model (adjust OR = 3.431, 95%CI = 1.060-11.103, <i>p</i> = 0.04). The interactions of <i>FABP1</i> rs2241883 and <i>FABP2</i> rs1799883 were not associated with IS risk (<i>p</i> = 0.172). Moreover, interaction analysis of two genes (rs1799883 and rs2241883) and two environmental factors (smoking and alcohol consumption) was associated with an increased risk of IS (<i>p</i> = 0.011). <b>Conclusion:</b> The GA genotype of FABP2 rs1799883, interactions between rs1799883, rs2241883 and smoking and alcohol consumption were associated with IS risk in Chinese Han populations.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2025-04-25T20:16:45.963Z","creation":"2025-04-06T08:17:18.678Z"},"accession":"S-EPMC10117902","cross_references":{"pubmed":["37091779"],"doi":["10.3389/fgene.2023.1056186"]}}