biostudies-literatureUnknown14Cao M<b>Background:</b> Dyslipidemia is an independent predictor of ischemic stroke (IS). Genetic variations in lipid-metabolism related genes may increase the risk of IS. Fatty acid-binding protein 1 (FABP1) and fatty acid-binding protein 2 (FABP2) are lipid chaperones responsible for lipid transport and metabolism. The present study aimed to determine the association between <i>FABP1</i> or <i>FABP2</i> and ischemic stroke. <b>Methods:</b> A total of 251 participants were recruited composed of 138 patients with ischemic stroke and 113 healthy subjects. DNA was extracted from peripheral blood samples. The rs2241883 polymorphism in <i>FABP1</i> and rs1799883 polymorphism in <i>FABP2</i> were genotyped using polymerase chain reaction-restriction fragment length polymorphism. Generalized multifactor dimensionality reduction (GMDR) was used to find out the interaction combinations between two SNPs and environmental factors. <b>Results:</b> The GA genotype of FABP2 rs1799883 increased susceptibility to ischemic stroke under overdominant inheritance model (<i>p</i> = 0.042). After adjusting for the risk factors of IS, it was associated with a significantly higher risk of IS in the codominant inheritance model (adjust OR = 3.431, 95%CI = 1.060-11.103, <i>p</i> = 0.04). The interactions of <i>FABP1</i> rs2241883 and <i>FABP2</i> rs1799883 were not associated with IS risk (<i>p</i> = 0.172). Moreover, interaction analysis of two genes (rs1799883 and rs2241883) and two environmental factors (smoking and alcohol consumption) was associated with an increased risk of IS (<i>p</i> = 0.011). <b>Conclusion:</b> The GA genotype of FABP2 rs1799883, interactions between rs1799883, rs2241883 and smoking and alcohol consumption were associated with IS risk in Chinese Han populations.Frontiers in genetics1056186https://www.ebi.ac.uk/biostudies/studies/S-EPMC10117902biostudies-literaturePolymorphism in genes encoding two fatty acid binding proteins increases risk of ischemic stroke in a Chinese Han population.PMC10117902Gong FLi XCao MYang LZhang YZhou CZhang XLiu BZhong JFang LChen DfalsePolymorphism in genes encoding two fatty acid binding proteins increases risk of ischemic stroke in a Chinese Han population.<b>Background:</b> Dyslipidemia is an independent predictor of ischemic stroke (IS). Genetic variations in lipid-metabolism related genes may increase the risk of IS. Fatty acid-binding protein 1 (FABP1) and fatty acid-binding protein 2 (FABP2) are lipid chaperones responsible for lipid transport and metabolism. The present study aimed to determine the association between <i>FABP1</i> or <i>FABP2</i> and ischemic stroke. <b>Methods:</b> A total of 251 participants were recruited composed of 138 patients with ischemic stroke and 113 healthy subjects. DNA was extracted from peripheral blood samples. The rs2241883 polymorphism in <i>FABP1</i> and rs1799883 polymorphism in <i>FABP2</i> were genotyped using polymerase chain reaction-restriction fragment length polymorphism. Generalized multifactor dimensionality reduction (GMDR) was used to find out the interaction combinations between two SNPs and environmental factors. <b>Results:</b> The GA genotype of FABP2 rs1799883 increased susceptibility to ischemic stroke under overdominant inheritance model (<i>p</i> = 0.042). After adjusting for the risk factors of IS, it was associated with a significantly higher risk of IS in the codominant inheritance model (adjust OR = 3.431, 95%CI = 1.060-11.103, <i>p</i> = 0.04). The interactions of <i>FABP1</i> rs2241883 and <i>FABP2</i> rs1799883 were not associated with IS risk (<i>p</i> = 0.172). Moreover, interaction analysis of two genes (rs1799883 and rs2241883) and two environmental factors (smoking and alcohol consumption) was associated with an increased risk of IS (<i>p</i> = 0.011). <b>Conclusion:</b> The GA genotype of FABP2 rs1799883, interactions between rs1799883, rs2241883 and smoking and alcohol consumption were associated with IS risk in Chinese Han populations.2023-01-01T00:00:00Z20232025-04-25T20:16:45.963Z2025-04-06T08:17:18.678ZS-EPMC101179023709177910.3389/fgene.2023.1056186