biostudies-literatureDeyama STakeda Science FoundationJapan Agency for Medical Research and DevelopmentUehara Memorial FoundationMochida Memorial Foundation for Medical and Pharmaceutical ResearchYOKOYAMA Foundation for Clinical PharmacologyHokkoku Cancer FoundationJapan Society for the Promotion of Science484-501https://www.ebi.ac.uk/biostudies/studies/S-EPMC10121976biostudies-literatureUnknown20(2)Intracerebroventricular infusion of resolvin E1 (RvE1), a bioactive metabolite derived from eicosapentaenoic acid, exerts antidepressant-like effects in a mouse model of lipopolysaccharide (LPS)-induced depression; these effects are blocked by systemic injection of rapamycin, a mechanistic target of rapamycin complex 1 (mTORC1) inhibitor. Additionally, local infusion of RvE1 into the medial prefrontal cortex (mPFC) or dorsal hippocampal dentate gyrus (DG) produces antidepressant-like effects. To evaluate the potential of RvE1 for clinical use, the present study examined whether treatment with RvE1 via intranasal (i.n.) route, a non-invasive route for effective drug delivery to the brain, produces antidepressant-like effects in LPS-challenged mice using tail suspension and forced swim testsNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeuticsIntranasal Administration of Resolvin E1 Produces Antidepressant-Like Effects via BDNF/VEGF-mTORC1 Signaling in the Medial Prefrontal Cortex.PMC10121976YRY-1903JP17K0836021gm0910012h0004JP19K07120JP19H01014Kaneda KAoki SDeyama SShuto SSugie RFukuda HMinami MfalseIntranasal Administration of Resolvin E1 Produces Antidepressant-Like Effects via BDNF/VEGF-mTORC1 Signaling in the Medial Prefrontal Cortex.Intracerebroventricular infusion of resolvin E1 (RvE1), a bioactive metabolite derived from eicosapentaenoic acid, exerts antidepressant-like effects in a mouse model of lipopolysaccharide (LPS)-induced depression; these effects are blocked by systemic injection of rapamycin, a mechanistic target of rapamycin complex 1 (mTORC1) inhibitor. Additionally, local infusion of RvE1 into the medial prefrontal cortex (mPFC) or dorsal hippocampal dentate gyrus (DG) produces antidepressant-like effects. To evaluate the potential of RvE1 for clinical use, the present study examined whether treatment with RvE1 via intranasal (i.n.) route, a non-invasive route for effective drug delivery to the brain, produces antidepressant-like effects in LPS-challenged mice using tail suspension and forced swim tests2023-01-01T00:00:00Z2023 Mar2026-06-02T19:25:40.176Z2025-04-04T20:40:53.043ZS-EPMC101219763662263410.1007/s13311-022-01337-1