biostudies-literatureUnknown4(1)Eagle SRSleep disturbances occur in up to 70% of patients with mild traumatic brain injury (mTBI). Modern mTBI management recommends targeted treatment for the patient's unique clinical manifestations (i.e., obstructive sleep apnea, insomnia). The purpose of this study was to evaluate the association of plasma biomarkers with symptom reports, overnight sleep evaluations, and response to treatment for sleep disturbances secondary to mTBI. This study is a secondary analysis of a prospective multiple interventional trial of patients with chronic issues related to mTBI. Pre- and post-intervention assessments were conducted, including overnight sleep apnea evaluation, the Pittsburgh Sleep Quality Index (PSQI), and blinded analysis of blood biomarkers. Bivariate Spearman correlations were conducted for Neurotrauma reports251-254https://www.ebi.ac.uk/biostudies/studies/S-EPMC10122241biostudies-literatureAssociation of Plasma Biomarkers with Sleep Outcomes and Treatment Response After Mild Traumatic Brain Injury.PMC10122241Schneider WMcIntyre PTollefson SOkonkwo DOEagle SRAgnone ANwafo RSoose RJAgoston DVCollins MMancinelli MPuccio AMKontos APfalseAssociation of Plasma Biomarkers with Sleep Outcomes and Treatment Response After Mild Traumatic Brain Injury.Sleep disturbances occur in up to 70% of patients with mild traumatic brain injury (mTBI). Modern mTBI management recommends targeted treatment for the patient's unique clinical manifestations (i.e., obstructive sleep apnea, insomnia). The purpose of this study was to evaluate the association of plasma biomarkers with symptom reports, overnight sleep evaluations, and response to treatment for sleep disturbances secondary to mTBI. This study is a secondary analysis of a prospective multiple interventional trial of patients with chronic issues related to mTBI. Pre- and post-intervention assessments were conducted, including overnight sleep apnea evaluation, the Pittsburgh Sleep Quality Index (PSQI), and blinded analysis of blood biomarkers. Bivariate Spearman correlations were conducted for 2023-01-01T00:00:00Z20232025-04-04T10:22:31.445Z2025-02-19T02:39:01.01ZS-EPMC101222413709585610.1089/neur.2023.0002