{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Duan Y"],"funding":["Guangzhou Basic and Applied Basic Research Foundation"],"pagination":["81"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10122320"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["Background
Heat shock protein 60 (HSP60) is essential for the folding and assembly of newly imported proteins to the mitochondria. HSP60 is overexpressed in most types of cancer, but its association with ovarian cancer is still in dispute. SKOV3 and OVCAR3 were used as experimental models after comparing the expression level of mitochondrial HSP60 in a normal human ovarian epithelial cell line and four ovarian cancer cell lines.Results
Low HSPD1 (Heat Shock Protein Family D (HSP60) Member 1) expression was associated with unfavorable prognosis in ovarian cancer patients. Knockdown of HSPD1 significantly promoted the proliferation and migration of ovarian cancer cells. The differentially expressed proteins after HSPD1 knockdown were enriched in the lipoic acid (LA) biosynthe"],"journal":["Journal of ovarian research"],"pubmed_title":["Knockdown of heat shock protein family D member 1 (HSPD1) promotes proliferation and migration of ovarian cancer cells via disrupting the stability of mitochondrial 3-oxoacyl-ACP synthase (OXSM)."],"pmcid":["PMC10122320"],"funding_grant_id":["No. 202102020103, No. 202102021031"],"pubmed_authors":["Liu H","Lash GE","Chen M","Lu S","Gan X","Yu J","Ye Y","Lu Q","Duan Y","Ning F"],"additional_accession":[]},"is_claimable":false,"name":"Knockdown of heat shock protein family D member 1 (HSPD1) promotes proliferation and migration of ovarian cancer cells via disrupting the stability of mitochondrial 3-oxoacyl-ACP synthase (OXSM).","description":"Background
Heat shock protein 60 (HSP60) is essential for the folding and assembly of newly imported proteins to the mitochondria. HSP60 is overexpressed in most types of cancer, but its association with ovarian cancer is still in dispute. SKOV3 and OVCAR3 were used as experimental models after comparing the expression level of mitochondrial HSP60 in a normal human ovarian epithelial cell line and four ovarian cancer cell lines.Results
Low HSPD1 (Heat Shock Protein Family D (HSP60) Member 1) expression was associated with unfavorable prognosis in ovarian cancer patients. Knockdown of HSPD1 significantly promoted the proliferation and migration of ovarian cancer cells. The differentially expressed proteins after HSPD1 knockdown were enriched in the lipoic acid (LA) biosynthe","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2025-04-20T00:15:47.257Z","creation":"2025-02-19T04:15:36.303Z"},"accession":"S-EPMC10122320","cross_references":{"pubmed":["37087461"],"doi":["10.1186/s13048-023-01156-8"]}}