biostudies-literatureZatzick DNIMH NIH HHSPatient-Centered Outcomes Research Institute288https://www.ebi.ac.uk/biostudies/studies/S-EPMC10122352biostudies-literatureUnknown24(1)<h4>Background</h4>Over the past two decades, pragmatic and implementation science clinical trial research methods have advanced substantially. Pragmatic and implementation studies have natural areas of overlap, particularly relating to the goal of using clinical trial data to leverage health care system policy changes. Few investigations have addressed pragmatic and implementation science randomized trial methods development while also considering policy impact.<h4>Methods</h4>The investigation used the PRagmatic Explanatory Continuum Indicator Summary-2 (PRECIS-2) and PRECIS-2-Provider Strategies (PRECIS-2-PS) tools to evaluate the design of two multisite randomized clinical trials that targeted patient-level effectiveness outcomes, provider-level practice changes and health care system TrialsIntegrating pragmatic and implementation science randomized clinical trial approaches: a PRagmatic Explanatory Continuum Indicator Summary-2 (PRECIS-2) analysis.PMC10122352IHS-2017C1-6151R01 MH130460Zatzick DPrater LIles-Shih MRusso JEngstrom AMoloney KPalinkas LWhiteside LWang JAbu KBulger EChambers DAfalseIntegrating pragmatic and implementation science randomized clinical trial approaches: a PRagmatic Explanatory Continuum Indicator Summary-2 (PRECIS-2) analysis.<h4>Background</h4>Over the past two decades, pragmatic and implementation science clinical trial research methods have advanced substantially. Pragmatic and implementation studies have natural areas of overlap, particularly relating to the goal of using clinical trial data to leverage health care system policy changes. Few investigations have addressed pragmatic and implementation science randomized trial methods development while also considering policy impact.<h4>Methods</h4>The investigation used the PRagmatic Explanatory Continuum Indicator Summary-2 (PRECIS-2) and PRECIS-2-Provider Strategies (PRECIS-2-PS) tools to evaluate the design of two multisite randomized clinical trials that targeted patient-level effectiveness outcomes, provider-level practice changes and health care system 2023-01-01T00:00:00Z2023 Apr2025-04-04T10:22:23.728Z2025-02-19T02:38:47.957ZS-EPMC101223523708587710.1186/s13063-023-07313-0