{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["43(3)"],"submitter":["Yang Z"],"pubmed_abstract":["<h4>Objective</h4>To investigate the therapeutic mechanism of diosmetin on 2, 4, 6-trinitrobenzene sulfonic acid (TNBS)-induced Crohn's disease (CD)-like colitis in mice.<h4>Methods</h4>Wild-type C57BL/6 mice were randomized into control group, TNBS-induced CD-like colitis group (TNBS group) and 50 mg·kg<sup>-1</sup>·d<sup>-1</sup> diosmetin-treated group (<i>n</i>=8). Disease activity (DAI) scores, body weight changes, histological scores, colon lengths and colon mucosal levels of TNF-α, IFN-γ, and IL-17A were measured to evaluate the severity of colitis. The changes of T lymphocyte subsets (Th1/Th2 and Th17/Treg) in the mesenteric lymph nodes were analyzed by flow cytometry. Network pharmacology and molecular docking were used to analyze the effect of diosmetin on PI3K/AKT pathway.<h4>Re"],"journal":["Nan fang yi ke da xue xue bao = Journal of Southern Medical University"],"pagination":["474-482"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10122747"],"repository":["biostudies-literature"],"pubmed_title":["[Diosmetin regulates intestinal immune balance by inhibiting PI3K/AKT signaling to relieve 2, 4, 6-trinitrobenzene sulfonic acid-induced Crohn's disease-like colitis in mice]."],"pmcid":["PMC10122747"],"pubmed_authors":["Ge S","Yang Z","Li Y","Zhang X","Zhao T","Wang X","Zuo L","Zhou Y","Cheng Y"],"additional_accession":[]},"is_claimable":false,"name":"[Diosmetin regulates intestinal immune balance by inhibiting PI3K/AKT signaling to relieve 2, 4, 6-trinitrobenzene sulfonic acid-induced Crohn's disease-like colitis in mice].","description":"<h4>Objective</h4>To investigate the therapeutic mechanism of diosmetin on 2, 4, 6-trinitrobenzene sulfonic acid (TNBS)-induced Crohn's disease (CD)-like colitis in mice.<h4>Methods</h4>Wild-type C57BL/6 mice were randomized into control group, TNBS-induced CD-like colitis group (TNBS group) and 50 mg·kg<sup>-1</sup>·d<sup>-1</sup> diosmetin-treated group (<i>n</i>=8). Disease activity (DAI) scores, body weight changes, histological scores, colon lengths and colon mucosal levels of TNF-α, IFN-γ, and IL-17A were measured to evaluate the severity of colitis. The changes of T lymphocyte subsets (Th1/Th2 and Th17/Treg) in the mesenteric lymph nodes were analyzed by flow cytometry. Network pharmacology and molecular docking were used to analyze the effect of diosmetin on PI3K/AKT pathway.<h4>Re","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Mar","modification":"2025-04-04T10:22:15.394Z","creation":"2025-02-19T02:39:05.205Z"},"accession":"S-EPMC10122747","cross_references":{"pubmed":["37087594"],"doi":["10.12122/j.issn.1673-4254.2023.03.19"]}}