biostudies-literatureSingh VMulti-Institute Research Facultyfcad100https://www.ebi.ac.uk/biostudies/studies/S-EPMC10123397biostudies-literatureUnknown5(2)The Theory of Mind deficit due to cognitive-affective disintegration is a poorly understood cognitive consequence of cortical and subcortical disruption in right temporal lobe epilepsy. Following Marr's trilevel approach, we used the material-specific processing model to understand the Theory of Mind deficit in drug-resistant epilepsy (<i>N</i> = 30). We examined pre- and post-surgery changes in first-order (somatic-affective, non-verbal component) and second-order Theory of Mind (cognitive-verbal component) in three groups formed using: (i) seizure side (right versus left), (ii) right temporal epilepsy (right temporal lobe epilepsy versus non-right temporal lobe epilepsy), and (iii) right temporal lobe epilepsy with amygdalohippocampectomy (right temporal lobe epilepsy versus left temporaBrain communicationsCortico-limbic disruption, material-specificity, and deficits in cognitive-affective theory of mind.PMC101233972018:39Singh RKChandra SPVibha DTripathi MRamanujam BGaikwad SBabu ISingh VGrewal KSNehra AfalseCortico-limbic disruption, material-specificity, and deficits in cognitive-affective theory of mind.The Theory of Mind deficit due to cognitive-affective disintegration is a poorly understood cognitive consequence of cortical and subcortical disruption in right temporal lobe epilepsy. Following Marr's trilevel approach, we used the material-specific processing model to understand the Theory of Mind deficit in drug-resistant epilepsy (<i>N</i> = 30). We examined pre- and post-surgery changes in first-order (somatic-affective, non-verbal component) and second-order Theory of Mind (cognitive-verbal component) in three groups formed using: (i) seizure side (right versus left), (ii) right temporal epilepsy (right temporal lobe epilepsy versus non-right temporal lobe epilepsy), and (iii) right temporal lobe epilepsy with amygdalohippocampectomy (right temporal lobe epilepsy versus left tempora2023-01-01T00:00:00Z20232025-07-02T03:04:19.064Z2025-04-06T08:02:51.05ZS-EPMC101233973710183310.1093/braincomms/fcad100