{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bang JW"],"funding":["NEI NIH HHS","Alcon Research Institute Young Investigator","BrightFocus Foundation","National Institutes of Health","United States Department of Defense","University Langone Health Department of Ophthalmology"],"pagination":["fcad119"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10123399"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["5(2)"],"pubmed_abstract":["Plasticity in the brain is impacted by an individual's age at the onset of the blindness. However, what drives the varying degrees of plasticity remains largely unclear. One possible explanation attributes the mechanisms for the differing levels of plasticity to the cholinergic signals originating in the nucleus basalis of Meynert. This explanation is based on the fact that the nucleus basalis of Meynert can modulate cortical processes such as plasticity and sensory encoding through its widespread cholinergic projections. Nevertheless, there is no direct evidence indicating that the nucleus basalis of Meynert undergoes plastic changes following blindness. Therefore, using multiparametric magnetic resonance imaging, we examined if the structural and functional properties of the nucleus basa"],"journal":["Brain communications"],"pubmed_title":["Diverging patterns of plasticity in the nucleus basalis of Meynert in early- and late-onset blindness."],"pmcid":["PMC10123399"],"funding_grant_id":["R01-EY028125","R01 EY013178","T32-EY017271)","W81XWH2110615)","G2021001F)","P30 EY008098","T32 EY017271","P30-EY008098","R01 EY028125"],"pubmed_authors":["Chan RW","Chan KC","Nau AC","Parra C","Murphy MC","Bang JW","Schuman JS"],"additional_accession":[]},"is_claimable":false,"name":"Diverging patterns of plasticity in the nucleus basalis of Meynert in early- and late-onset blindness.","description":"Plasticity in the brain is impacted by an individual's age at the onset of the blindness. However, what drives the varying degrees of plasticity remains largely unclear. One possible explanation attributes the mechanisms for the differing levels of plasticity to the cholinergic signals originating in the nucleus basalis of Meynert. This explanation is based on the fact that the nucleus basalis of Meynert can modulate cortical processes such as plasticity and sensory encoding through its widespread cholinergic projections. Nevertheless, there is no direct evidence indicating that the nucleus basalis of Meynert undergoes plastic changes following blindness. Therefore, using multiparametric magnetic resonance imaging, we examined if the structural and functional properties of the nucleus basa","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2026-05-28T16:50:48.226Z","creation":"2024-10-18T18:31:33.908Z"},"accession":"S-EPMC10123399","cross_references":{"pubmed":["37101831"],"doi":["10.1093/braincomms/fcad119"]}}