{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["30(2)"],"submitter":["Collins LK"],"pubmed_abstract":["Aging causes a reduction in testosterone and estrogen, which is linked to diminished bone mineral density. Hormone replacement therapy and its effect on the outcome of joint arthroplasties is unclear. The purpose of this study was to analyze the impact of testosterone replacement therapy (TRT) and estrogen replacement therapy (ERT) on the medical and joint outcomes of total hip (THA) and total knee arthroplasties (TKA). A retrospective cohort study was conducted using the PearlDiver database. Patients who received TRT or ERT perioperatively were matched to controls. Rates of 90-day medical complications and 2-year joint complications were queried. Patients who received TRT had an increased risk of revision, periprosthetic joint infection, and pooled joint complications within 2 years follo"],"journal":["Pathophysiology : the official journal of the International Society for Pathophysiology"],"pagination":["123-135"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10123744"],"repository":["biostudies-literature"],"pubmed_title":["Hormone Replacement Therapy Does Not Eliminate Risk Factors for Joint Complications following Total Joint Arthroplasty: A Matched Cohort Study."],"pmcid":["PMC10123744"],"pubmed_authors":["Massey PA","Sherman WF","Waters TL","Collins LK","Iloanya M","Cole MW"],"additional_accession":[]},"is_claimable":false,"name":"Hormone Replacement Therapy Does Not Eliminate Risk Factors for Joint Complications following Total Joint Arthroplasty: A Matched Cohort Study.","description":"Aging causes a reduction in testosterone and estrogen, which is linked to diminished bone mineral density. Hormone replacement therapy and its effect on the outcome of joint arthroplasties is unclear. The purpose of this study was to analyze the impact of testosterone replacement therapy (TRT) and estrogen replacement therapy (ERT) on the medical and joint outcomes of total hip (THA) and total knee arthroplasties (TKA). A retrospective cohort study was conducted using the PearlDiver database. Patients who received TRT or ERT perioperatively were matched to controls. Rates of 90-day medical complications and 2-year joint complications were queried. Patients who received TRT had an increased risk of revision, periprosthetic joint infection, and pooled joint complications within 2 years follo","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2025-04-19T07:25:02.506Z","creation":"2025-02-19T04:15:52.989Z"},"accession":"S-EPMC10123744","cross_references":{"pubmed":["37092525"],"doi":["10.3390/pathophysiology30020011"]}}