{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["McCoy ME"],"funding":["NIDDK NIH HHS","University of Southern California","Children&apos;s Hospital Los Angeles"],"pagination":["ENEURO.0511-22.2023"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10124152"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(4)"],"pubmed_abstract":["Vagal sensory neurons (VSNs) located in the nodose ganglion provide information, such as stomach stretch or the presence of ingested nutrients, to the caudal medulla via specialized cell types expressing unique marker genes. Here, we leverage VSN marker genes identified in adult mice to determine when specialized vagal subtypes arise developmentally and the trophic factors that shape their growth. Experiments to screen for trophic factor sensitivity revealed that brain-derived neurotrophic factor (BDNF) and glial cell-derived neurotrophic factor (GDNF) robustly stimulate neurite outgrowth from VSNs <i>in vitro</i> Perinatally, BDNF was expressed by neurons of the nodose ganglion itself, while GDNF was expressed by intestinal smooth muscle cells. Thus, BDNF may support VSNs locally, whereas"],"journal":["eNeuro"],"pubmed_title":["Ontogeny and Trophic Factor Sensitivity of Gastrointestinal Projecting Vagal Sensory Cell Types."],"pmcid":["PMC10124152"],"funding_grant_id":["DNNP Startup","R01 DK126085","Core Pilot Award","R01 DK084142","Stem Cell Challenge Award"],"pubmed_authors":["Kamitakahara AK","McCoy ME"],"additional_accession":[]},"is_claimable":false,"name":"Ontogeny and Trophic Factor Sensitivity of Gastrointestinal Projecting Vagal Sensory Cell Types.","description":"Vagal sensory neurons (VSNs) located in the nodose ganglion provide information, such as stomach stretch or the presence of ingested nutrients, to the caudal medulla via specialized cell types expressing unique marker genes. Here, we leverage VSN marker genes identified in adult mice to determine when specialized vagal subtypes arise developmentally and the trophic factors that shape their growth. Experiments to screen for trophic factor sensitivity revealed that brain-derived neurotrophic factor (BDNF) and glial cell-derived neurotrophic factor (GDNF) robustly stimulate neurite outgrowth from VSNs <i>in vitro</i> Perinatally, BDNF was expressed by neurons of the nodose ganglion itself, while GDNF was expressed by intestinal smooth muscle cells. Thus, BDNF may support VSNs locally, whereas","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2026-06-24T03:15:58.776Z","creation":"2025-02-19T02:38:43.237Z"},"accession":"S-EPMC10124152","cross_references":{"pubmed":["36973009"],"doi":["10.1523/ENEURO.0511-22.2023"]}}