{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Klee M"],"funding":["NIA NIH HHS","National Institute for Health Research (NIHR)","Wellcome Trust"],"pagination":["621-630"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10126314"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["64(5)"],"pubmed_abstract":["<h4>Introduction</h4>Socioeconomic factors and genetic predisposition are established risk factors for dementia. It remains unclear whether associations of socioeconomic deprivation with dementia incidence are modified by genetic risk.<h4>Methods</h4>Participants in the UK Biobank aged ≥60 years and of European ancestry without dementia at baseline (2006-2010) were eligible for the analysis, with the main exposures area-level deprivation based on the Townsend Deprivation Index and individual-level socioeconomic deprivation based on car and home ownership, housing type and income, and polygenic risk of dementia. Dementia was ascertained in hospital and death records. Analysis was conducted in 2021.<h4>Results</h4>In this cohort study, 196,368 participants (mean [SD] age=64.1 [2.9] years, 52"],"journal":["American journal of preventive medicine"],"pubmed_title":["Socioeconomic Deprivation, Genetic Risk, and Incident Dementia."],"pmcid":["PMC10126314"],"funding_grant_id":["RF1 AG055654"],"pubmed_authors":["Klee M","Ranson JM","Leist AK","Llewellyn DJ","Veldsman M"],"additional_accession":[]},"is_claimable":false,"name":"Socioeconomic Deprivation, Genetic Risk, and Incident Dementia.","description":"<h4>Introduction</h4>Socioeconomic factors and genetic predisposition are established risk factors for dementia. It remains unclear whether associations of socioeconomic deprivation with dementia incidence are modified by genetic risk.<h4>Methods</h4>Participants in the UK Biobank aged ≥60 years and of European ancestry without dementia at baseline (2006-2010) were eligible for the analysis, with the main exposures area-level deprivation based on the Townsend Deprivation Index and individual-level socioeconomic deprivation based on car and home ownership, housing type and income, and polygenic risk of dementia. Dementia was ascertained in hospital and death records. Analysis was conducted in 2021.<h4>Results</h4>In this cohort study, 196,368 participants (mean [SD] age=64.1 [2.9] years, 52","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 May","modification":"2025-06-25T03:04:20.228Z","creation":"2025-06-25T03:04:20.228Z"},"accession":"S-EPMC10126314","cross_references":{"pubmed":["37085245"],"doi":["10.1016/j.amepre.2023.01.012"]}}