biostudies-literatureUnknown14Yu YH<h4>Introduction</h4>Understanding the modulations of the medial prefrontal cortex (mPFC) in the valence of the stimulus from rewarding and aversive status to neutral status is crucial for the development of novel treatments for drug addiction. This study addressed this issue and examined whether optogenetic ChR2 photostimulation in the cingulate, prelimbic, and infralimbic cortices of the mPFC regulated the valence of saccharin solution consumption from the rewarding property, the aversive property induced by morphine's conditioning, and the neutral states <i>via</i> saccharin extinction processes after morphine's conditioning.<h4>Methods</h4>All rats received virus infection, buried optical fiber, optical stimulation, water deprivation, and saccharin solution consumption phases. In ExperFrontiers in psychiatry1119803https://www.ebi.ac.uk/biostudies/studies/S-EPMC10126430biostudies-literatureOptogenetic stimulation in the medial prefrontal cortex modulates stimulus valence from rewarding and aversive to neutral states.PMC10126430Chang FCTsai ACHuang ACWYu YHShyu BCOu CYCheng CNfalseOptogenetic stimulation in the medial prefrontal cortex modulates stimulus valence from rewarding and aversive to neutral states.<h4>Introduction</h4>Understanding the modulations of the medial prefrontal cortex (mPFC) in the valence of the stimulus from rewarding and aversive status to neutral status is crucial for the development of novel treatments for drug addiction. This study addressed this issue and examined whether optogenetic ChR2 photostimulation in the cingulate, prelimbic, and infralimbic cortices of the mPFC regulated the valence of saccharin solution consumption from the rewarding property, the aversive property induced by morphine's conditioning, and the neutral states <i>via</i> saccharin extinction processes after morphine's conditioning.<h4>Methods</h4>All rats received virus infection, buried optical fiber, optical stimulation, water deprivation, and saccharin solution consumption phases. In Exper2023-01-01T00:00:00Z20232025-04-06T02:21:05.316Z2025-04-06T02:21:05.316ZS-EPMC101264303711354510.3389/fpsyt.2023.1119803