biostudies-literatureTredup CBristol-Myers SquibbPfizerBayerRoyal Institution for the Advancement of Learning McGill UniversityOntario Institute for Cancer ResearchGenentechDeutsche ForschungsgemeinschaftHorizon 2020 Framework ProgrammeTakeda Pharmaceutical CompanyKungliga Tekniska HoegskolanDeutschen Konsortium für Translationale KrebsforschungBoehringer IngelheimInnovative Health InitiativeMerck KGaALOEWE Zentrum AdRIADiamond Light SourceGenome CanadaJanssen Pharmaceuticals822-836https://www.ebi.ac.uk/biostudies/studies/S-EPMC10127199biostudies-literatureUnknown18(4)Well-characterized small molecules are essential tools for studying the biology and therapeutic relevance of a target protein. However, many compounds reported in the literature and routinely studied in biomedical research lack the potency and selectivity required for mechanistic cellular studies on the function of a given protein. Furthermore, commercially available compounds often do not include useful tools developed by industry as part of their research and development efforts, as they frequently remain proprietary. The freely available donated chemical probe (DCP) library, fueled by generous donations of compounds from industry and academia, enables easy access to a steadily growing collection of these valuable and well-characterized tools. Here, we provide a systematic description ofACS chemical biologyDeep Annotation of Donated Chemical Probes (DCP) in Organotypic Human Liver Cultures and Patient-Derived Organoids from Tumor and Normal Colorectum.PMC101271998755101399INST 161/920-1 FUGG1177III L 5 - 519/03/03.001 - (0015)Tredup CKnapp SBerger BTMuller STjaden ARohm SYouhanna SFarin HFBerger LMKramer ANdreshkjana BSchneider NSLauschke VMKemas AMfalseDeep Annotation of Donated Chemical Probes (DCP) in Organotypic Human Liver Cultures and Patient-Derived Organoids from Tumor and Normal Colorectum.Well-characterized small molecules are essential tools for studying the biology and therapeutic relevance of a target protein. However, many compounds reported in the literature and routinely studied in biomedical research lack the potency and selectivity required for mechanistic cellular studies on the function of a given protein. Furthermore, commercially available compounds often do not include useful tools developed by industry as part of their research and development efforts, as they frequently remain proprietary. The freely available donated chemical probe (DCP) library, fueled by generous donations of compounds from industry and academia, enables easy access to a steadily growing collection of these valuable and well-characterized tools. Here, we provide a systematic description of2023-01-01T00:00:00Z2023 Apr2026-05-29T03:15:31.493Z2024-12-04T10:47:34.207ZS-EPMC101271993694437110.1021/acschembio.2c00877