biostudies-literatureUnknown12(2)Maulat C<h4>Background</h4>Liver resection and local ablation are the only curative treatment for non-cirrhotic hepatocellular carcinoma (HCC). Few data exist concerning the prognosis of patients resected for non-cirrhotic HCC. The objectives of this study were to determine the prognostic factors of recurrence-free survival (RFS) and overall survival (OS) and to develop a prognostication algorithm for non-cirrhotic HCC.<h4>Methods</h4>French multicenter retrospective study including HCC patients with non-cirrhotic liver without underlying viral hepatitis: F0, F1 or F2 fibrosis.<h4>Results</h4>A total of 467 patients were included in 11 centers from 2010 to 2018. Non-cirrhotic liver had a fibrosis score of F0 (n=237, 50.7%), F1 (n=127, 27.2%) or F2 (n=103, 22.1%). OS and RFS at 5 years were 59.2% aHepatobiliary surgery and nutrition192-204https://www.ebi.ac.uk/biostudies/studies/S-EPMC10129883biostudies-literaturePrognostication algorithm for non-cirrhotic non-B non-C hepatocellular carcinoma-a multicenter study under the aegis of the French Association of Hepato-Biliary Surgery and liver Transplantation.PMC10129883Tranchart HAndrieu SMuscari FEl Amrani MSuc BFuks DNotte AToubert CHobeika CHerrero AProdeau MSalame EShourick JCauchy FTruant SMaulat CBarbier LRegimbeau JMGagniere JGirard EDoussot AfalsePrognostication algorithm for non-cirrhotic non-B non-C hepatocellular carcinoma-a multicenter study under the aegis of the French Association of Hepato-Biliary Surgery and liver Transplantation.<h4>Background</h4>Liver resection and local ablation are the only curative treatment for non-cirrhotic hepatocellular carcinoma (HCC). Few data exist concerning the prognosis of patients resected for non-cirrhotic HCC. The objectives of this study were to determine the prognostic factors of recurrence-free survival (RFS) and overall survival (OS) and to develop a prognostication algorithm for non-cirrhotic HCC.<h4>Methods</h4>French multicenter retrospective study including HCC patients with non-cirrhotic liver without underlying viral hepatitis: F0, F1 or F2 fibrosis.<h4>Results</h4>A total of 467 patients were included in 11 centers from 2010 to 2018. Non-cirrhotic liver had a fibrosis score of F0 (n=237, 50.7%), F1 (n=127, 27.2%) or F2 (n=103, 22.1%). OS and RFS at 5 years were 59.2% a2023-01-01T00:00:00Z2023 Apr2025-06-28T03:05:07.999Z2025-04-04T19:19:12.466ZS-EPMC101298833712467710.21037/hbsn-22-33