{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Vinson AJ"],"funding":["Bill & Melinda Gates Foundation","NCATS NIH HHS","NIGMS NIH HHS"],"pagination":["1035-1047"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10129906"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(7)"],"pubmed_abstract":["Exogenous estrogen is associated with reduced coronavirus disease (COVID) mortality in nonimmunosuppressed/immunocompromised (non-ISC) postmenopausal females. Here, we examined the association of estrogen or testosterone hormone replacement therapy (HRT) with COVID outcomes in solid organ transplant recipients (SOTRs) compared to non-ISC individuals, given known differences in sex-based risk in these populations. SOTRs ≥45 years old with COVID-19 between April 1, 2020 and July 31, 2022 were identified using the National COVID Cohort Collaborative. The association of HRT use in the last 24 months (exogenous systemic estrogens for females; testosterone for males) with major adverse renal or cardiac events in the 90 days post-COVID diagnosis and other secondary outcomes were examined using mu"],"journal":["American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons"],"pubmed_title":["Hormone replacement therapy and COVID-19 outcomes in solid organ transplant recipients compared with the general population."],"pmcid":["PMC10129906"],"funding_grant_id":["UL1 TR002494","UL1 TR002373","U54 GM115371","INV-018455","UL1 TR003142","UL1 TR002378","UL1 TR002014","UL1 TR002377","UL1 TR001442","UL1 TR001881","UL1 TR002537","UL1 TR002535","UL1 TR002733","UL1 TR001445","UL1 TR003107","UL1 TR002538","UL1 TR002736","UL1 TR001449","UL1 TR001409","U54 GM115458","UL1 TR001450","UL1 TR002384","UL1 TR002544","UL1 TR002345","UL1 TR002389","UL1 TR001453","UL1 TR002541","UL1 TR001855","UL1 TR001414","UL1 TR001412","U54 GM104938","UL1 TR002550","UL1 TR001422","UL1 TR001860","UL1 TR002553","UL1 TR001420","UL1 TR003167","UL1 TR001866","UL1 TR001425","UL1 TR002556","U24 TR002306","UL1 TR001863","UL1 TR002319","UL1 TR001427","U54 GM115677","UL1 TR003096","U54 GM115516","UL1 TR002243","UL1 TR002001","UL1 TR003015","UL1 TR003017","UL1 TR002240","UL1 TR001433","UL1 TR002489","UL1 TR001873","UL1 TR003098","UL1 TR001872","UL1 TR002366","UL1 TR002003","UL1 TR001430","U54 GM104941","UL1 TR001998","UL1 TR001876","U54 GM104940","UL1 TR001436","UL1 TR002645","UL1 TR002369","UL1 TR002529","UL1 TR001439","UL1 TR002649","U54 GM104942","UL1 TR001878","U54 GM115428"],"pubmed_authors":["Eichmann DA","Clark J","Deacy M","Patel B","Michael SG","Clark M","Dillon C","Sadan O","Hong SS","Gordon V","Bramante C","Martin G","Lehmann H","Bradwell KR","Patel R","Mariona F","Burgoon PW","Cooper W","Wilkins K","Ward-Caviness C","Harper JR","Gagnier J","Prior F","Zampino E","Setoguchi S","Safdar N","Garbarini N","Girvin AT","Guinney J","Palchuk MB","Cato KD","Suver C","Saltz JH","Qureshi N","Fuentes R","Sidky H","Manna A","Williams AE","Kurilla MG","Zhou A","Misquitta L","Mathew J","Madlock-Brown C","Saltz MM","Saha A","Olex A","Bennett TD","Subbian V","Mallipattu S","Portilla L","Wilcox AB","Boudreau E","Adams M","Erwin-Cohen R","Emmett M","Moffitt RA","Haendel MA","Dai R","Callahan T","Sheikh U","Pincavitch J","Koraishy FM","Anzalone A","McMurry JA","Northington L","Chute C","Gabriel D","Jawa R","Wu C","Pfaff ER","Ge J","Mehta H","Lee AM","Anzalone AJ","Brown D","Amor B","Rutter JL","Zhu RL","Hill E","Kibbe WA","Murray K","Pyles LA","Housman D","Gersing KR","Starren J","Hendricks B","Zhang XT","Southerland A","Buse J","Takemoto C","Temple-O'Connor M","O'Neil ST","Loomba J","Beasley W","Bates B","Marti EC","Kamaleswaran R","Hurley R","Islam J","Mazzotti D","Saltz J","Sharafeldin N","Liu H","Crowley K","Mannon RB","Spratt H","Olex AL","Walters KM","Francis PA","Vedula S","Johnson S","Pyarajan S","Walden A","Bissell MM","Schissel M","Alexander C","Bozzette S","Morris M","Hayanga JWA","Sokos G","Vinson AJ","Graves A","Cottrell L","Hillegass W","Hernandez W","Sharathkumar AA","Robinson P","French E","National COVID Cohort Collaborative","Chapman S","Payne PRO","Topaloglu U","Miller RT","Kostka K","French ET","Schmitt C"],"additional_accession":[]},"is_claimable":false,"name":"Hormone replacement therapy and COVID-19 outcomes in solid organ transplant recipients compared with the general population.","description":"Exogenous estrogen is associated with reduced coronavirus disease (COVID) mortality in nonimmunosuppressed/immunocompromised (non-ISC) postmenopausal females. Here, we examined the association of estrogen or testosterone hormone replacement therapy (HRT) with COVID outcomes in solid organ transplant recipients (SOTRs) compared to non-ISC individuals, given known differences in sex-based risk in these populations. SOTRs ≥45 years old with COVID-19 between April 1, 2020 and July 31, 2022 were identified using the National COVID Cohort Collaborative. The association of HRT use in the last 24 months (exogenous systemic estrogens for females; testosterone for males) with major adverse renal or cardiac events in the 90 days post-COVID diagnosis and other secondary outcomes were examined using mu","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jul","modification":"2025-04-21T17:12:12.043Z","creation":"2024-11-20T09:15:30.724Z"},"accession":"S-EPMC10129906","cross_references":{"pubmed":["37105315"],"doi":["10.1016/j.ajt.2023.04.020"]}}