{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liu K"],"funding":["The Project of the Education Department of Zhejiang Province"],"pagination":["158"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10131379"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["28(1)"],"pubmed_abstract":["<h4>Background</h4>Metabolic biomarkers are reported to be associated with the risk of lung cancer (LC). However, the observed associations from epidemiological studies are either inconsistent or inconclusive.<h4>Methods</h4>The genetic summary data of high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), total cholesterol (TC), triglyceride (TG), fasting plasma glucose (FPG), and glycated hemoglobin (HbA1c) and those of the LC and its histological subtypes were retrieved from previous GWASs. We performed two-sample Mendelian randomization (MR) and multivariable MR analyses to examine the associations between genetically predicted metabolic biomarkers and LC in East Asians and Europeans.<h4>Results</h4>In East Asians, the inverse-variance weighted (IVW) met"],"journal":["European journal of medical research"],"pubmed_title":["Genetic associations between circulating metabolic biomarkers and lung cancer in East Asians and Europeans."],"pmcid":["PMC10131379"],"funding_grant_id":["Y201839109"],"pubmed_authors":["Song L","Liu Y","Huang S","Liu K","He Z","Wang S","Zhou Y"],"additional_accession":[]},"is_claimable":false,"name":"Genetic associations between circulating metabolic biomarkers and lung cancer in East Asians and Europeans.","description":"<h4>Background</h4>Metabolic biomarkers are reported to be associated with the risk of lung cancer (LC). However, the observed associations from epidemiological studies are either inconsistent or inconclusive.<h4>Methods</h4>The genetic summary data of high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), total cholesterol (TC), triglyceride (TG), fasting plasma glucose (FPG), and glycated hemoglobin (HbA1c) and those of the LC and its histological subtypes were retrieved from previous GWASs. We performed two-sample Mendelian randomization (MR) and multivariable MR analyses to examine the associations between genetically predicted metabolic biomarkers and LC in East Asians and Europeans.<h4>Results</h4>In East Asians, the inverse-variance weighted (IVW) met","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2025-05-29T19:43:09.643Z","creation":"2025-04-04T11:05:26.827Z"},"accession":"S-EPMC10131379","cross_references":{"pubmed":["37101305"],"doi":["10.1186/s40001-023-01116-4"]}}