{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhong Z"],"funding":["NIGMS NIH HHS"],"pagination":["96"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10131428"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(1)"],"pubmed_abstract":["Background
The microrchidia (MORC) proteins are a family of evolutionarily conserved GHKL-type ATPases involved in chromatin compaction and gene silencing. Arabidopsis MORC proteins act in the RNA-directed DNA methylation (RdDM) pathway, where they act as molecular tethers to ensure the efficient establishment of RdDM and de novo gene silencing. However, MORC proteins also have RdDM-independent functions although their underlying mechanisms are unknown.Results
In this study, we examine MORC binding regions where RdDM does not occur in order to shed light on the RdDM-independent functions of MORC proteins. We find that MORC proteins compact chromatin and reduce DNA accessibility to transcription factors, thereby repressing gene expression. We also find that MORC-mediated rep"],"journal":["Genome biology"],"pubmed_title":["MORC proteins regulate transcription factor binding by mediating chromatin compaction in active chromatin regions."],"pmcid":["PMC10131428"],"funding_grant_id":["R35 GM130272"],"pubmed_authors":["Wang M","Ke Y","Li Z","Liu M","Harris CJ","Jami-Alahmadi Y","Zhong Z","Feng S","Wohlschlegel JA","Xue Y","Zhou J","Jacobsen SE"],"additional_accession":[]},"is_claimable":false,"name":"MORC proteins regulate transcription factor binding by mediating chromatin compaction in active chromatin regions.","description":"Background
The microrchidia (MORC) proteins are a family of evolutionarily conserved GHKL-type ATPases involved in chromatin compaction and gene silencing. Arabidopsis MORC proteins act in the RNA-directed DNA methylation (RdDM) pathway, where they act as molecular tethers to ensure the efficient establishment of RdDM and de novo gene silencing. However, MORC proteins also have RdDM-independent functions although their underlying mechanisms are unknown.Results
In this study, we examine MORC binding regions where RdDM does not occur in order to shed light on the RdDM-independent functions of MORC proteins. We find that MORC proteins compact chromatin and reduce DNA accessibility to transcription factors, thereby repressing gene expression. We also find that MORC-mediated rep","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2025-04-22T13:10:25.258Z","creation":"2025-04-06T00:33:44.594Z"},"accession":"S-EPMC10131428","cross_references":{"pubmed":["37101218"],"doi":["10.1186/s13059-023-02939-4"]}}