{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(3)"],"submitter":["Klotz C"],"funding":["Western Norway Regional Health Authority","Deutsche Forschungsgemeinschaft","Charles University, Prague, Czech Republic","Horizon 2020"],"pubmed_abstract":["<i>Giardia duodenalis</i> (syn. <i>G. intestinalis, G. lamblia</i>) is a widespread gastrointestinal protozoan parasite with debated taxonomic status. Currently, eight distinct genetic sub-groups, termed assemblages A-H, are defined based on a few genetic markers. Assemblages A and B may represent distinct species and are both of human public health relevance. Genomic studies are scarce and the few reference genomes available, in particular for assemblage B, are insufficient for adequate comparative genomics. Here, by combining long- and short-read sequences generated by PacBio and Illumina sequencing technologies, we provide nine annotated genome sequences for reference from new clinical isolates (four assemblage A and five assemblage B parasite isolates). Isolates chosen represent the cu"],"journal":["Microbial genomics"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10132058"],"repository":["biostudies-literature"],"pubmed_title":["Highly contiguous genomes of human clinical isolates of <i>Giardia duodenalis</i> reveal assemblage- and sub-assemblage-specific presence-absence variation in protein-coding genes."],"pmcid":["PMC10132058"],"funding_grant_id":["911571 and 912245","911897","Priority Program SPP 2332","643476 (COMPARE project)","GRK2046 Research Training Program","773830 (PARADISE project)","PRIMUS/20/MED/008"],"pubmed_authors":["Aebischer T","Langeland N","Klotz C","Schmid MW","Caccio SM","Saghaug CS","Lalle M","Winter K","Hanevik K","Weisz F","Ignatius R","Dawson S"],"additional_accession":[]},"is_claimable":false,"name":"Highly contiguous genomes of human clinical isolates of <i>Giardia duodenalis</i> reveal assemblage- and sub-assemblage-specific presence-absence variation in protein-coding genes.","description":"<i>Giardia duodenalis</i> (syn. <i>G. intestinalis, G. lamblia</i>) is a widespread gastrointestinal protozoan parasite with debated taxonomic status. Currently, eight distinct genetic sub-groups, termed assemblages A-H, are defined based on a few genetic markers. Assemblages A and B may represent distinct species and are both of human public health relevance. Genomic studies are scarce and the few reference genomes available, in particular for assemblage B, are insufficient for adequate comparative genomics. Here, by combining long- and short-read sequences generated by PacBio and Illumina sequencing technologies, we provide nine annotated genome sequences for reference from new clinical isolates (four assemblage A and five assemblage B parasite isolates). Isolates chosen represent the cu","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Mar","modification":"2026-05-28T19:42:50.057Z","creation":"2024-12-04T10:46:33.235Z"},"accession":"S-EPMC10132058","cross_references":{"pubmed":["36976254"],"doi":["10.1099/mgen.0.000963"]}}