biostudies-literatureUnknown9(3)Sudatip DSwiss National Science FoundationSouth-East Asian countries report a high prevalence of extended-spectrum cephalosporin- (ESC-) and colistin-resistant <i>Escherichia coli</i> (Col-R-<i>Ec</i>). However, there are still few studies describing the molecular mechanisms and transmission dynamics of ESC-R-<i>Ec</i> and, especially, Col-R-<i>Ec</i>. This study aimed to evaluate the prevalence and transmission dynamics of <i>Ec</i> containing extended spectrum beta-lactamases (ESBL) and mobile colistin resistance (<i>mcr</i>) genes using a 'One Health' design in Thailand. The ESC-R-<i>Ec</i> and Col-R-<i>Ec</i> isolates of human stool samples (69 pig farmers, 155 chicken farmers, and 61 non-farmers), rectal swabs from animals (269 pigs and 318 chickens), and the intestinal contents of 196 rodents were investigated. Resistance meMicrobial genomicshttps://www.ebi.ac.uk/biostudies/studies/S-EPMC10132067biostudies-literatureThe risk of pig and chicken farming for carriage and transmission of <i>Escherichia coli</i> containing extended-spectrum beta-lactamase (ESBL) and mobile colistin resistance (<i>mcr</i>) genes in Thailand.PMC10132067IZJFZ3-177614Sudatip DAbdallah RRolain JMPhanprasit WHilty MTiengrim SThamlikitkul VChasiri KOppliger AKritiyakan AMorand SThinphovong CMostacci NBaron SAfalseThe risk of pig and chicken farming for carriage and transmission of <i>Escherichia coli</i> containing extended-spectrum beta-lactamase (ESBL) and mobile colistin resistance (<i>mcr</i>) genes in Thailand.South-East Asian countries report a high prevalence of extended-spectrum cephalosporin- (ESC-) and colistin-resistant <i>Escherichia coli</i> (Col-R-<i>Ec</i>). However, there are still few studies describing the molecular mechanisms and transmission dynamics of ESC-R-<i>Ec</i> and, especially, Col-R-<i>Ec</i>. This study aimed to evaluate the prevalence and transmission dynamics of <i>Ec</i> containing extended spectrum beta-lactamases (ESBL) and mobile colistin resistance (<i>mcr</i>) genes using a 'One Health' design in Thailand. The ESC-R-<i>Ec</i> and Col-R-<i>Ec</i> isolates of human stool samples (69 pig farmers, 155 chicken farmers, and 61 non-farmers), rectal swabs from animals (269 pigs and 318 chickens), and the intestinal contents of 196 rodents were investigated. Resistance me2023-01-01T00:00:00Z2023 Mar2026-05-29T06:37:24.703Z2025-02-19T02:04:01.338ZS-EPMC101320673695191210.1099/mgen.0.000951