{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(3)"],"submitter":["Dusadeepong R"],"pubmed_abstract":["In early 2020, the Medical Biology Laboratory of the Pasteur Institute of Cambodia isolated an unusually high number of fluoroquinolone-resistant <i>Salmonella enterica</i> subspecies <i>enterica</i> serovar Paratyphi A strains during its routine bacteriological surveillance activities in Phnom Penh, Cambodia. A public-health investigation was supported by genome sequencing of these Paratyphi A strains to gain insights into the genetic diversity and population structure of a potential outbreak of fluoroquinolone-resistant paratyphoid fever. Comparative genomic and phylodynamic analyses revealed the 2020 strains were descended from a previously described 2013-2015 outbreak of Paratyphi A infections. Our analysis showed sub-lineage 2.3.1 had remained largely susceptible to fluoroquinolone dr"],"journal":["Microbial genomics"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10132074"],"repository":["biostudies-literature"],"pubmed_title":["Phylogenomic investigation of an outbreak of fluoroquinolone-resistant <i>Salmonella enterica</i> subsp. <i>enterica</i> serovar Paratyphi A in Phnom Penh, Cambodia."],"pmcid":["PMC10132074"],"pubmed_authors":["Choun K","Meng S","Hardy L","Glaser P","Vandelannoote K","Dusadeepong R","Teav S","Cheng S","Hoang T","Jacobs J","Stinear TP","Letchford J","Howden BP","Sreng N","Seemann T","Delvallez G"],"additional_accession":[]},"is_claimable":false,"name":"Phylogenomic investigation of an outbreak of fluoroquinolone-resistant <i>Salmonella enterica</i> subsp. <i>enterica</i> serovar Paratyphi A in Phnom Penh, Cambodia.","description":"In early 2020, the Medical Biology Laboratory of the Pasteur Institute of Cambodia isolated an unusually high number of fluoroquinolone-resistant <i>Salmonella enterica</i> subspecies <i>enterica</i> serovar Paratyphi A strains during its routine bacteriological surveillance activities in Phnom Penh, Cambodia. A public-health investigation was supported by genome sequencing of these Paratyphi A strains to gain insights into the genetic diversity and population structure of a potential outbreak of fluoroquinolone-resistant paratyphoid fever. Comparative genomic and phylodynamic analyses revealed the 2020 strains were descended from a previously described 2013-2015 outbreak of Paratyphi A infections. Our analysis showed sub-lineage 2.3.1 had remained largely susceptible to fluoroquinolone dr","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Mar","modification":"2026-07-14T21:07:59.546Z","creation":"2025-02-19T02:04:05.202Z"},"accession":"S-EPMC10132074","cross_references":{"pubmed":["36961484"],"doi":["10.1099/mgen.0.000972"]}}