{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Premadasa LS"],"funding":["NIDA NIH HHS","NIAID NIH HHS","NIMH NIH HHS","National Institute on Drug Abuse","NIH HHS"],"pagination":["e167903"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10132162"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(7)"],"pubmed_abstract":["Intestinal epithelial barrier dysfunction, a hallmark of HIV/SIV infection, persists despite viral suppression by combination antiretroviral therapy (cART). Emerging evidence suggests a critical role for long noncoding RNAs (lncRNAs) in maintaining epithelial homeostasis. We simultaneously profiled lncRNA/mRNA expression exclusively in colonic epithelium (CE) of SIV-infected rhesus macaques (RMs) administered vehicle (VEH) or Δ-9-tetrahydrocannabinol (THC). Relative to controls, fewer lncRNAs were up- or downregulated in CE of THC/SIV compared with VEH/SIV RMs. Importantly, reciprocal expression of the natural antisense lncRNA MMP25-AS1 (up 2.3-fold) and its associated protein-coding gene MMP25 (attracts neutrophils by inactivating alpha-1 anti-trypsin/SERPINA1) (down 2.2-fold) was detecte"],"journal":["JCI insight"],"pubmed_title":["Cannabinoid enhancement of lncRNA MMP25-AS1/MMP25 interaction reduces neutrophil infiltration and intestinal epithelial injury in HIV/SIV infection."],"pmcid":["PMC10132162"],"funding_grant_id":["P30 AI161943","P51 OD011104","R01 MH116844","R01 DA052845","R33 DA053643","P51 OD011133","R01DA042524,R01DA052845,R01DA050169,P30AI161943,P51OD011104,P51OD111033","R01 DA050169","R01 MH130193","U42 OD010442","R56 AI150371","R01 AI157850","R01 DA042524"],"pubmed_authors":["Jayakumar S","Mohan M","Alvarez X","Ling B","McDew-White M","Premadasa LS","Okeoma CM","Byrareddy SN","Kulkarni S","Lee E"],"additional_accession":[]},"is_claimable":false,"name":"Cannabinoid enhancement of lncRNA MMP25-AS1/MMP25 interaction reduces neutrophil infiltration and intestinal epithelial injury in HIV/SIV infection.","description":"Intestinal epithelial barrier dysfunction, a hallmark of HIV/SIV infection, persists despite viral suppression by combination antiretroviral therapy (cART). Emerging evidence suggests a critical role for long noncoding RNAs (lncRNAs) in maintaining epithelial homeostasis. We simultaneously profiled lncRNA/mRNA expression exclusively in colonic epithelium (CE) of SIV-infected rhesus macaques (RMs) administered vehicle (VEH) or Δ-9-tetrahydrocannabinol (THC). Relative to controls, fewer lncRNAs were up- or downregulated in CE of THC/SIV compared with VEH/SIV RMs. Importantly, reciprocal expression of the natural antisense lncRNA MMP25-AS1 (up 2.3-fold) and its associated protein-coding gene MMP25 (attracts neutrophils by inactivating alpha-1 anti-trypsin/SERPINA1) (down 2.2-fold) was detecte","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2026-05-29T06:37:33.804Z","creation":"2025-02-19T02:04:05.813Z"},"accession":"S-EPMC10132162","cross_references":{"pubmed":["37036007"],"doi":["10.1172/jci.insight.167903"]}}