{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["616(7958)"],"submitter":["Gaia M"],"pubmed_abstract":["DNA viruses have a major influence on the ecology and evolution of cellular organisms<sup>1-4</sup>, but their overall diversity and evolutionary trajectories remain elusive<sup>5</sup>. Here we carried out a phylogeny-guided genome-resolved metagenomic survey of the sunlit oceans and discovered plankton-infecting relatives of herpesviruses that form a putative new phylum dubbed Mirusviricota. The virion morphogenesis module of this large monophyletic clade is typical of viruses from the realm Duplodnaviria<sup>6</sup>, with multiple components strongly indicating a common ancestry with animal-infecting Herpesvirales. Yet, a substantial fraction of mirusvirus genes, including hallmark transcription machinery genes missing in herpesviruses, are closely related homologues of giant eukaryotic"],"journal":["Nature"],"pagination":["783-789"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10132985"],"repository":["biostudies-literature"],"pubmed_title":["Mirusviruses link herpesviruses to giant viruses."],"pmcid":["PMC10132985"],"pubmed_authors":["Ogata H","Forterre P","Fernandez-Guerra A","Pelletier E","Jaillon O","Meng L","Krupovic M","Wincker P","Delmont TO","Vanni C","Gaia M"],"additional_accession":[]},"is_claimable":false,"name":"Mirusviruses link herpesviruses to giant viruses.","description":"DNA viruses have a major influence on the ecology and evolution of cellular organisms<sup>1-4</sup>, but their overall diversity and evolutionary trajectories remain elusive<sup>5</sup>. Here we carried out a phylogeny-guided genome-resolved metagenomic survey of the sunlit oceans and discovered plankton-infecting relatives of herpesviruses that form a putative new phylum dubbed Mirusviricota. The virion morphogenesis module of this large monophyletic clade is typical of viruses from the realm Duplodnaviria<sup>6</sup>, with multiple components strongly indicating a common ancestry with animal-infecting Herpesvirales. Yet, a substantial fraction of mirusvirus genes, including hallmark transcription machinery genes missing in herpesviruses, are closely related homologues of giant eukaryotic","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2025-07-10T03:08:14.101Z","creation":"2025-04-04T22:11:44.284Z"},"accession":"S-EPMC10132985","cross_references":{"pubmed":["37076623"],"doi":["10.1038/s41586-023-05962-4"]}}