biostudies-literatureUnknown13(1)Kim DMChosun UniversityThis study analyzed HGA and SFTS in patients with suspected tick-borne infection by focusing on key differences that clinicians can easily recognize. A retrospective analysis was performed on confirmed patients with HGA or SFTS in 21 Korean hospitals from 2013 to 2020. A scoring system was developed by multivariate regression analysis and accuracy assessment of clinically easily discriminable parameters was performed. The multivariate logistic regression analysis revealed that sex (especially male sex) (odds ratio [OR] 11.45, P = 0.012), neutropenia (< 1500) (OR 41.64, P < 0.001), prolonged activated partial thromboplastin time (OR 80.133, P < 0.001), and normal C-reactive protein concentration (≤ 1.0 mg/dL; OR 166.855, P = 0.001) were significantly associated with SFTS but not with HGA. EScientific reports6837https://www.ebi.ac.uk/biostudies/studies/S-EPMC10133271biostudies-literatureClinically differential diagnosis of human granulocytic anaplasmosis and severe fever with thrombocytopenia syndrome.PMC10133271Lee SHur JHeo JYJung SILim SLee SHKim ESKim JKim CMKim DMYun NRJeong HWKim DYKim UJSeo JWKwak YGKim YKKim SEYu BJJung DSPark SHChatterjee SKim HAfalseClinically differential diagnosis of human granulocytic anaplasmosis and severe fever with thrombocytopenia syndrome.This study analyzed HGA and SFTS in patients with suspected tick-borne infection by focusing on key differences that clinicians can easily recognize. A retrospective analysis was performed on confirmed patients with HGA or SFTS in 21 Korean hospitals from 2013 to 2020. A scoring system was developed by multivariate regression analysis and accuracy assessment of clinically easily discriminable parameters was performed. The multivariate logistic regression analysis revealed that sex (especially male sex) (odds ratio [OR] 11.45, P = 0.012), neutropenia (< 1500) (OR 41.64, P < 0.001), prolonged activated partial thromboplastin time (OR 80.133, P < 0.001), and normal C-reactive protein concentration (≤ 1.0 mg/dL; OR 166.855, P = 0.001) were significantly associated with SFTS but not with HGA. E2023-01-01T00:00:00Z2023 Apr2025-04-22T10:04:39.993Z2025-04-05T23:23:13.454ZS-EPMC101332713710078210.1038/s41598-023-32061-1