{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14"],"submitter":["Yang X"],"pubmed_abstract":["As a Traditional Chinese Medicine prescription, Qingjin Yiqi Granules (QJYQ) provides an effective treatment for patients recovering from COVID-19. However, the pharmacokinetics characteristics of the main components of QJYQ <i>in vivo</i> are still unknown. An efficacious ultra-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) was developed and validated for the simultaneous determination of 33 components in rat plasma after oral administration of QJYQ. The plasma samples were precipitated with 400 µL methanol/acetonitrile (1/1, <i>v</i>/<i>v</i>) and analyzed in scheduled multiple reaction monitoring mode. The linear relationship of the 33 components was good (r > 0.9928). The lower limit of quantification for 33 components ranged from 0.4-60.5 ng/mL. The average r"],"journal":["Frontiers in pharmacology"],"pagination":["1155973"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10133546"],"repository":["biostudies-literature"],"pubmed_title":["Simultaneous determination of multiple components in rat plasma by UHPLC-sMRM for pharmacokinetic studies after oral administration of Qingjin Yiqi Granules."],"pmcid":["PMC10133546"],"pubmed_authors":["Yang X","Li J","Zhang H","Shang Y","Fang S","Chen S","Du K","Chang Y"],"additional_accession":[]},"is_claimable":false,"name":"Simultaneous determination of multiple components in rat plasma by UHPLC-sMRM for pharmacokinetic studies after oral administration of Qingjin Yiqi Granules.","description":"As a Traditional Chinese Medicine prescription, Qingjin Yiqi Granules (QJYQ) provides an effective treatment for patients recovering from COVID-19. However, the pharmacokinetics characteristics of the main components of QJYQ <i>in vivo</i> are still unknown. An efficacious ultra-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) was developed and validated for the simultaneous determination of 33 components in rat plasma after oral administration of QJYQ. The plasma samples were precipitated with 400 µL methanol/acetonitrile (1/1, <i>v</i>/<i>v</i>) and analyzed in scheduled multiple reaction monitoring mode. The linear relationship of the 33 components was good (r > 0.9928). The lower limit of quantification for 33 components ranged from 0.4-60.5 ng/mL. The average r","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2025-05-29T19:43:08.856Z","creation":"2025-05-29T19:43:08.856Z"},"accession":"S-EPMC10133546","cross_references":{"pubmed":["37124227"],"doi":["10.3389/fphar.2023.1155973"]}}