biostudies-literatureUnknown158(7)Arjona-Sanchez A<h4>Importance</h4>Peritoneal metastasis in patients with locally advanced colon cancer (T4 stage) is estimated to recur at a rate of approximately 25% at 3 years from surgical resection and is associated with poor prognosis. There is controversy regarding the clinical benefit of prophylactic hyperthermic intraperitoneal chemotherapy (HIPEC) in these patients.<h4>Objective</h4>To assess the efficacy and safety of intraoperative HIPEC in patients with locally advanced colon cancer.<h4>Design, setting, and participants</h4>This open-label, phase 3 randomized clinical trial was conducted in 17 Spanish centers from November 15, 2015, to March 9, 2021. Enrolled patients were aged 18 to 75 years with locally advanced primary colon cancer diagnosed preoperatively (cT4N02M0).<h4>Interventions</h4>JAMA surgery683-691https://www.ebi.ac.uk/biostudies/studies/S-EPMC10134040biostudies-literatureEfficacy and Safety of Intraoperative Hyperthermic Intraperitoneal Chemotherapy for Locally Advanced Colon Cancer: A Phase 3 Randomized Clinical Trial.PMC10134040Carrasco-Campos JBoldo-Roda EGonzalez Cordero MBriceno-Delgado JGomez Sanz RMorales Soriano RRuiz Marin MMoneva Arce MEHernandez Juara PArtiles-Armas MRomero-Ruiz AOrtega-Perez GPerez-Viejo EHernandez Hernandez GMartinez Lopez AMolina Villaverde RSanchez Gonzalez JMLasa Unzue ICrusellas Mana OHeras Garceau MAValenzuela Molina FCarrasco Prats MMedina Fernandez FJPineno Flores CSerrano Del Moral ALopez Garcia AGarcia Molina FVina Romero MMMunoz Hernandez ABusteros Moraza JIGarzas Martin de Almagro CLorenzo Linan MATrivino Tarradas FRamirez Faraco MBarrios-Sanchez PHernandez Barroso MJDiaz-Lopez CCano-Osuna MTGrupo Español de Carcinomatosis PeritonealAbreu FalconGallarin Salamanca IMAfonso Gomez RVazquez Borrego MCCastro Lopez-Tarruella VRufian Andujar BManzanedo IDiaz Mejias JGEspinosa-Redondo EGordon Suarez ARodriguez-Ortiz LOrtega Salas RMSegura-Sampedro JJPrada-Villaverde AAranda ETitos Garcia ADiez Alonso MParra Banos PAGutierrez-Calvo AVillar CPrieto-Nieto IGonzalez Moreno SCasado-Adam AGomez Espana AConcepcion-Martin VVillarejo-Campos PRufian-Pena SPereira FTorres-Melero JArjona-Sanchez AGranados Rodriguez MCastillo Torres CTorres Tordera EMHernandez Perez CSanchez-Hidalgo JMPerez Rodriguez RRamos IDiaz Lopez CGianchandani Moorjani RMayol Oltra ATerol Garaulet ESanchez-Garcia SGarcia-Fadrique AfalseEfficacy and Safety of Intraoperative Hyperthermic Intraperitoneal Chemotherapy for Locally Advanced Colon Cancer: A Phase 3 Randomized Clinical Trial.<h4>Importance</h4>Peritoneal metastasis in patients with locally advanced colon cancer (T4 stage) is estimated to recur at a rate of approximately 25% at 3 years from surgical resection and is associated with poor prognosis. There is controversy regarding the clinical benefit of prophylactic hyperthermic intraperitoneal chemotherapy (HIPEC) in these patients.<h4>Objective</h4>To assess the efficacy and safety of intraoperative HIPEC in patients with locally advanced colon cancer.<h4>Design, setting, and participants</h4>This open-label, phase 3 randomized clinical trial was conducted in 17 Spanish centers from November 15, 2015, to March 9, 2021. Enrolled patients were aged 18 to 75 years with locally advanced primary colon cancer diagnosed preoperatively (cT4N02M0).<h4>Interventions</h4>2023-01-01T00:00:00Z2023 Jul2026-06-01T19:57:33.239Z2026-05-20T03:07:40.535ZS-EPMC101340403709928010.1001/jamasurg.2023.0662