{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(4)"],"submitter":["Schilloks MC"],"pubmed_abstract":["Laron syndrome (LS) is a rare genetic disorder characterized by low levels of insulin-like growth factor 1 (IGF1) and high levels of growth hormone (GH) due to mutations in the growth hormone receptor gene (<i>GHR</i>). A <i>GHR</i>-knockout (<i>GHR</i>-KO) pig was developed as a model for LS, which displays many of the same features as humans with LS-like transient juvenile hypoglycemia. This study aimed to investigate the effects of impaired GHR signaling on immune functions and immunometabolism in <i>GHR</i>-KO pigs. GHR are located on various cell types of the immune system. Therefore, we investigated lymphocyte subsets, proliferative and respiratory capacity of peripheral blood mononuclear cells (PBMCs), proteome profiles of CD4<sup>-</sup> and CD4<sup>+</sup> lymphocytes and IFN-α se"],"journal":["Biomolecules"],"pagination":["597"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10135491"],"repository":["biostudies-literature"],"pubmed_title":["Effects of GHR Deficiency and Juvenile Hypoglycemia on Immune Cells of a Porcine Model for Laron Syndrome."],"pmcid":["PMC10135491"],"pubmed_authors":["Giese IM","Schilloks MC","Wolf E","Deeg CA","Hinrichs A","Korbonits L","Hauck SM"],"additional_accession":[]},"is_claimable":false,"name":"Effects of GHR Deficiency and Juvenile Hypoglycemia on Immune Cells of a Porcine Model for Laron Syndrome.","description":"Laron syndrome (LS) is a rare genetic disorder characterized by low levels of insulin-like growth factor 1 (IGF1) and high levels of growth hormone (GH) due to mutations in the growth hormone receptor gene (<i>GHR</i>). A <i>GHR</i>-knockout (<i>GHR</i>-KO) pig was developed as a model for LS, which displays many of the same features as humans with LS-like transient juvenile hypoglycemia. This study aimed to investigate the effects of impaired GHR signaling on immune functions and immunometabolism in <i>GHR</i>-KO pigs. GHR are located on various cell types of the immune system. Therefore, we investigated lymphocyte subsets, proliferative and respiratory capacity of peripheral blood mononuclear cells (PBMCs), proteome profiles of CD4<sup>-</sup> and CD4<sup>+</sup> lymphocytes and IFN-α se","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Mar","modification":"2026-04-08T12:16:45.294Z","creation":"2024-11-20T02:01:35.574Z"},"accession":"S-EPMC10135491","cross_references":{"pubmed":["37189345"],"doi":["10.3390/biom13040597"]}}