biostudies-literatureUnknown13(4)Schilloks MCLaron syndrome (LS) is a rare genetic disorder characterized by low levels of insulin-like growth factor 1 (IGF1) and high levels of growth hormone (GH) due to mutations in the growth hormone receptor gene (<i>GHR</i>). A <i>GHR</i>-knockout (<i>GHR</i>-KO) pig was developed as a model for LS, which displays many of the same features as humans with LS-like transient juvenile hypoglycemia. This study aimed to investigate the effects of impaired GHR signaling on immune functions and immunometabolism in <i>GHR</i>-KO pigs. GHR are located on various cell types of the immune system. Therefore, we investigated lymphocyte subsets, proliferative and respiratory capacity of peripheral blood mononuclear cells (PBMCs), proteome profiles of CD4^- and CD4⁺ lymphocytes and IFN-α seBiomolecules597https://www.ebi.ac.uk/biostudies/studies/S-EPMC10135491biostudies-literatureEffects of GHR Deficiency and Juvenile Hypoglycemia on Immune Cells of a Porcine Model for Laron Syndrome.PMC10135491Giese IMSchilloks MCWolf EDeeg CAHinrichs AKorbonits LHauck SMfalseEffects of GHR Deficiency and Juvenile Hypoglycemia on Immune Cells of a Porcine Model for Laron Syndrome.Laron syndrome (LS) is a rare genetic disorder characterized by low levels of insulin-like growth factor 1 (IGF1) and high levels of growth hormone (GH) due to mutations in the growth hormone receptor gene (<i>GHR</i>). A <i>GHR</i>-knockout (<i>GHR</i>-KO) pig was developed as a model for LS, which displays many of the same features as humans with LS-like transient juvenile hypoglycemia. This study aimed to investigate the effects of impaired GHR signaling on immune functions and immunometabolism in <i>GHR</i>-KO pigs. GHR are located on various cell types of the immune system. Therefore, we investigated lymphocyte subsets, proliferative and respiratory capacity of peripheral blood mononuclear cells (PBMCs), proteome profiles of CD4^- and CD4⁺ lymphocytes and IFN-α se2023-01-01T00:00:00Z2023 Mar2026-04-08T12:16:45.294Z2024-11-20T02:01:35.574ZS-EPMC101354913718934510.3390/biom13040597