{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Osipov AV"],"funding":["Vietnamese Academy of Sciences and Technology","Russian Foundation for Basic Research"],"pagination":["1115"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10136136"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(4)"],"pubmed_abstract":["Protozoal infections are a world-wide problem. The toxicity and somewhat low effectiveness of the existing drugs require the search for new ways of protozoa suppression. Snake venom contains structurally diverse components manifesting antiprotozoal activity; for example, those in cobra venom are cytotoxins. In this work, we aimed to characterize a novel antiprotozoal component(s) in the <i>Bungarus multicinctus</i> krait venom using the ciliate <i>Tetrahymena pyriformis</i> as a model organism. To determine the toxicity of the substances under study, surviving ciliates were registered automatically by an original BioLaT-3.2 instrument. The krait venom was separated by three-step liquid chromatography and the toxicity of the obtained fractions against <i>T. pyriformis</i> was analyzed. As a"],"journal":["Biomedicines"],"pubmed_title":["The Potassium Channel Blocker β-Bungarotoxin from the Krait <i>Bungarus multicinctus</i> Venom Manifests Antiprotozoal Activity."],"pmcid":["PMC10136136"],"funding_grant_id":["21-54-54005","QTRU01.15/21-22"],"pubmed_authors":["Cheremnykh EG","Hoang AN","Starkov VG","Utkin YN","Nguyen TTT","Tsetlin VI","Osipov AV","Nguyen KC","Le DT","Ziganshin RH"],"additional_accession":[]},"is_claimable":false,"name":"The Potassium Channel Blocker β-Bungarotoxin from the Krait <i>Bungarus multicinctus</i> Venom Manifests Antiprotozoal Activity.","description":"Protozoal infections are a world-wide problem. The toxicity and somewhat low effectiveness of the existing drugs require the search for new ways of protozoa suppression. Snake venom contains structurally diverse components manifesting antiprotozoal activity; for example, those in cobra venom are cytotoxins. In this work, we aimed to characterize a novel antiprotozoal component(s) in the <i>Bungarus multicinctus</i> krait venom using the ciliate <i>Tetrahymena pyriformis</i> as a model organism. To determine the toxicity of the substances under study, surviving ciliates were registered automatically by an original BioLaT-3.2 instrument. The krait venom was separated by three-step liquid chromatography and the toxicity of the obtained fractions against <i>T. pyriformis</i> was analyzed. As a","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2025-04-22T05:17:02.18Z","creation":"2025-04-05T21:16:51.698Z"},"accession":"S-EPMC10136136","cross_references":{"pubmed":["37189733"],"doi":["10.3390/biomedicines11041115"]}}