biostudies-literatureKita AJapan Society for the Promotion of Science1371https://www.ebi.ac.uk/biostudies/studies/S-EPMC10137239biostudies-literatureUnknown13(8)This study aimed to develop a new convolutional neural network (CNN) method for estimating the specific binding ratio (SBR) from only frontal projection images in single-photon emission-computed tomography using [¹²³I]ioflupane. We created five datasets to train two CNNs, LeNet and AlexNet: (1) 128FOV used a 0° projection image without preprocessing, (2) 40FOV used 0° projection images cropped to 40 × 40 pixels centered on the striatum, (3) 40FOV training data doubled by data augmentation (40FOV_DA, left-right reversal only), (4) 40FOVhalf, and (5) 40FOV_DAhalf, split into left and right (20 × 40) images of 40FOV and 40FOV_DA to separately evaluate the left and right SBR. The accuracy of the SBR estimation was assessed using the mean absolute error, root mean squared error, corrDiagnostics (Basel, Switzerland)Specific Binding Ratio Estimation of [¹²³I]-FP-CIT SPECT Using Frontal Projection Image and Machine Learning.PMC10137239JP2K15842Kosaka NKita ATsujikawa TOkazawa HKidoya ESugimoto KfalseSpecific Binding Ratio Estimation of [¹²³I]-FP-CIT SPECT Using Frontal Projection Image and Machine Learning.This study aimed to develop a new convolutional neural network (CNN) method for estimating the specific binding ratio (SBR) from only frontal projection images in single-photon emission-computed tomography using [¹²³I]ioflupane. We created five datasets to train two CNNs, LeNet and AlexNet: (1) 128FOV used a 0° projection image without preprocessing, (2) 40FOV used 0° projection images cropped to 40 × 40 pixels centered on the striatum, (3) 40FOV training data doubled by data augmentation (40FOV_DA, left-right reversal only), (4) 40FOVhalf, and (5) 40FOV_DAhalf, split into left and right (20 × 40) images of 40FOV and 40FOV_DA to separately evaluate the left and right SBR. The accuracy of the SBR estimation was assessed using the mean absolute error, root mean squared error, corr2023-01-01T00:00:00Z2023 Apr2025-04-22T05:17:44.326Z2025-04-05T21:16:59.619ZS-EPMC101372393718947210.3390/diagnostics13081371