biostudies-literatureWiglusz KMinistry of Science and Higher EducationNational Science Center271https://www.ebi.ac.uk/biostudies/studies/S-EPMC10137577biostudies-literatureUnknown9(4)The aim of this work was to prepare a new hydrogel based on nanohydroxyapatite (nFAP, 10% <i>w/w</i>) and fluorides (4% <i>w/w</i>), both of which are used as sources of fluoride ions in the treatment of dentin hypersensitivity, and to characterize its physicochemical properties. The release of fluoride ions from 3 gels (G-F, G-F-nFAP, and G-nFAP gel) was controlled in Fusayama-Meyer artificial saliva at pH 4.5, 6.6, and 8.0. The properties of the formulations were determined by an analysis of viscosity, a shear rate test, a swelling study, and gel aging. Various methods, i.e., FT-IR spectroscopy, UV-VIS spectroscopy, and thermogravimetric, electrochemical, and rheological analysis, were used for the experiment. The profiles of fluoride release indicate that the amount of fluoride ions relGels (Basel, Switzerland)Nanofluorapatite Hydrogels in the Treatment of Dentin Hypersensitivity: A Study of Physiochemical Properties and Fluoride Release.PMC10137577MINI.B180.22.007SUBZ.D290.23.031UMO-2021/43/B/ST5/02960Wiglusz KDobrzynski MWiglusz RJGutbier MfalseNanofluorapatite Hydrogels in the Treatment of Dentin Hypersensitivity: A Study of Physiochemical Properties and Fluoride Release.The aim of this work was to prepare a new hydrogel based on nanohydroxyapatite (nFAP, 10% <i>w/w</i>) and fluorides (4% <i>w/w</i>), both of which are used as sources of fluoride ions in the treatment of dentin hypersensitivity, and to characterize its physicochemical properties. The release of fluoride ions from 3 gels (G-F, G-F-nFAP, and G-nFAP gel) was controlled in Fusayama-Meyer artificial saliva at pH 4.5, 6.6, and 8.0. The properties of the formulations were determined by an analysis of viscosity, a shear rate test, a swelling study, and gel aging. Various methods, i.e., FT-IR spectroscopy, UV-VIS spectroscopy, and thermogravimetric, electrochemical, and rheological analysis, were used for the experiment. The profiles of fluoride release indicate that the amount of fluoride ions rel2023-01-01T00:00:00Z2023 Mar2025-04-04T11:05:12.479Z2025-04-04T11:05:12.479ZS-EPMC101375773710288310.3390/gels9040271