{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lu K"],"funding":["The National Key R&D Program of China"],"pagination":["1671"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10138103"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(8)"],"pubmed_abstract":["<i>Saccharina japonica</i> belongs to brown macro-alga with various potential health benefits; its antioxidant and anti-inflammatory activities indicate the potential to improve inflammatory bowel diseases. Here, the potential anti-colitis effect of <i>Saccharina japonica</i> extract (SJE) was evaluated on dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) in C57B/L6 mice. The mice were treated with mesalazine (MES) and various doses of SJE by gavage for 14 days. Results showed that both MES and SJE treatment decreased the disease activity index scores, relieving the short colon. SJE increased the occludin and zonula occludens-1 levels, and the beneficial effects were better than MES. MES and SJE exerted similar effects in decreasing inflammatory cytokines and oxidative stress. M"],"journal":["Foods (Basel, Switzerland)"],"pubmed_title":["<i>Saccharina japonica</i> Ethanol Extract Ameliorates Dextran Sulfate Sodium-Induced Colitis via Reshaping Intestinal Microenvironment and Alleviating Inflammatory Response."],"pmcid":["PMC10138103"],"funding_grant_id":["2018YFD0901105"],"pubmed_authors":["Lu K","Lin P","Ni L","Xie W","Liu L","Dong X","Che H"],"additional_accession":[]},"is_claimable":false,"name":"<i>Saccharina japonica</i> Ethanol Extract Ameliorates Dextran Sulfate Sodium-Induced Colitis via Reshaping Intestinal Microenvironment and Alleviating Inflammatory Response.","description":"<i>Saccharina japonica</i> belongs to brown macro-alga with various potential health benefits; its antioxidant and anti-inflammatory activities indicate the potential to improve inflammatory bowel diseases. Here, the potential anti-colitis effect of <i>Saccharina japonica</i> extract (SJE) was evaluated on dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) in C57B/L6 mice. The mice were treated with mesalazine (MES) and various doses of SJE by gavage for 14 days. Results showed that both MES and SJE treatment decreased the disease activity index scores, relieving the short colon. SJE increased the occludin and zonula occludens-1 levels, and the beneficial effects were better than MES. MES and SJE exerted similar effects in decreasing inflammatory cytokines and oxidative stress. M","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2025-04-21T22:47:34.35Z","creation":"2025-04-05T18:57:15.4Z"},"accession":"S-EPMC10138103","cross_references":{"pubmed":["37107466"],"doi":["10.3390/foods12081671"]}}