{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Luetkemeyer AF"],"funding":["National Institute of Allergy and Infectious Diseases","NIAID NIH HHS","NIMH NIH HHS","NINR NIH HHS"],"pagination":["1296-1306"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10140182"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["388(14)"],"pubmed_abstract":["<h4>Background</h4>Interventions to reduce sexually transmitted infections (STIs) among men who have sex with men (MSM) are needed.<h4>Methods</h4>We conducted an open-label, randomized study involving MSM and transgender women who were taking preexposure prophylaxis (PrEP) against human immunodeficiency virus (HIV) infection (PrEP cohort) or living with HIV infection (persons living with HIV infection [PLWH] cohort) and who had had <i>Neisseria gonorrhoeae</i> (gonorrhea), <i>Chlamydia trachomatis</i> (chlamydia), or syphilis in the past year. Participants were randomly assigned in a 2:1 ratio to take 200 mg of doxycycline within 72 hours after condomless sex (doxycycline postexposure prophylaxis) or receive standard care without doxycycline. STI testing was performed quarterly. The prima"],"journal":["The New England journal of medicine"],"pubmed_title":["Postexposure Doxycycline to Prevent Bacterial Sexually Transmitted Infections."],"pmcid":["PMC10140182"],"funding_grant_id":["P30 AI027757","P30 MH123248","R01 AI143439","T32 NR019761"],"pubmed_authors":["DoxyPEP Study Team","Sankaran M","Perkins R","Nassar M","Christopoulos K","Gandhi M","Cohee A","Barnabas R","Donnell D","Havlir D","Brown C","Hawman E","Soge OO","Brown CE","Bauer M","Bender-Ignacio R","Kimsey C","Coleman K","Nasser M","Haller B","Malinski C","Vittinghoff E","Herrmann S","Pham P","Sanchez Guerrero Y","Bainbridge E","Cannon C","Celum C","Mathis J","Dwyer J","Masinde G","Molina JM","Jacobs E","Langelier C","Alfaro CR","Lawton S","Luetkemeyer AF","Ramchandani M","Scott H","Reyes-Umana L","Thibault C","Moretz B","Grant S","Peluso M","Martens S","Dombrowski JC","Stephanie S","Hamilton D","Metter M","Padilla R","Charlebois ED","Fredericksen R","Johnson R","Legg L","Ocbamichael N","Gonzaga C","Kim J","Viar V","Havlir DV","Thomas K","Baeten J","Ikuma M","Golden M","Barash E","Lopez C","Buchbinder SP","Rechkina E","Wong J","Boyer J","Friend J","Dombrowski J","Piper Y","Nguyen T","Soge O","Yassin S","Tamakloe S","Cohen S","Hickey M","Grabow C","Black D","Haugen H","Cimmiyotti D","Vinson J","Alves da Costa E Silva N","Faber E","Buchbinder S","Velasco J","Dunaway S","Okochi H","Eugenio MA","Hicks ML","Luetkemeyer A"],"additional_accession":[]},"is_claimable":false,"name":"Postexposure Doxycycline to Prevent Bacterial Sexually Transmitted Infections.","description":"<h4>Background</h4>Interventions to reduce sexually transmitted infections (STIs) among men who have sex with men (MSM) are needed.<h4>Methods</h4>We conducted an open-label, randomized study involving MSM and transgender women who were taking preexposure prophylaxis (PrEP) against human immunodeficiency virus (HIV) infection (PrEP cohort) or living with HIV infection (persons living with HIV infection [PLWH] cohort) and who had had <i>Neisseria gonorrhoeae</i> (gonorrhea), <i>Chlamydia trachomatis</i> (chlamydia), or syphilis in the past year. Participants were randomly assigned in a 2:1 ratio to take 200 mg of doxycycline within 72 hours after condomless sex (doxycycline postexposure prophylaxis) or receive standard care without doxycycline. STI testing was performed quarterly. The prima","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2026-05-28T11:09:32.79Z","creation":"2025-04-04T12:49:00.634Z"},"accession":"S-EPMC10140182","cross_references":{"pubmed":["37018493"],"doi":["10.1056/NEJMoa2211934","10.1056/nejmoa2211934"]}}