{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sui Y"],"funding":["Kobe University","Japan Society for the Promotion of Science"],"pagination":["444-457"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10140238"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["58(5)"],"pubmed_abstract":["<h4>Background</h4>Amino acid transporters play an important role in supplying nutrition to cells and are associated with cell proliferation. L-type amino acid transporter 1 (LAT1) is highly expressed in many types of cancers and promotes tumor growth; however, how LAT1 affects tumor development is not fully understood.<h4>Methods</h4>To investigate the role of LAT1 in intestinal tumorigenesis, mice carrying LAT1 floxed alleles that also expressed Cre recombinase from the promoter of gene encoding Villin were crossed to an Apc<sup>Min/+</sup> background (LAT1<sup>fl/fl</sup>; vil-cre; Apc<sup>Min/+</sup>), which were subject to analysis; organoids derived from those mice were also analyzed.<h4>Results</h4>This study showed that LAT1 was constitutively expressed in normal crypt base cells, "],"journal":["Journal of gastroenterology"],"pubmed_title":["LAT1 expression influences Paneth cell number and tumor development in Apc<sup>Min/+</sup> mice."],"pmcid":["PMC10140238"],"funding_grant_id":["20H04123","19K08421"],"pubmed_authors":["Ku Y","Sasaki K","Kong L","Kinoshita M","Yoshida R","Ito Y","Sui Y","Kotani T","Shinohara M","Kanai Y","Tokunaga E","Tian Z","Matozaki T","Ohgaki R","Watanabe D","Hoshi N","Kodama Y","Miyazaki H","Okamoto N","Ooi M","Zen Y"],"additional_accession":[]},"is_claimable":false,"name":"LAT1 expression influences Paneth cell number and tumor development in Apc<sup>Min/+</sup> mice.","description":"<h4>Background</h4>Amino acid transporters play an important role in supplying nutrition to cells and are associated with cell proliferation. L-type amino acid transporter 1 (LAT1) is highly expressed in many types of cancers and promotes tumor growth; however, how LAT1 affects tumor development is not fully understood.<h4>Methods</h4>To investigate the role of LAT1 in intestinal tumorigenesis, mice carrying LAT1 floxed alleles that also expressed Cre recombinase from the promoter of gene encoding Villin were crossed to an Apc<sup>Min/+</sup> background (LAT1<sup>fl/fl</sup>; vil-cre; Apc<sup>Min/+</sup>), which were subject to analysis; organoids derived from those mice were also analyzed.<h4>Results</h4>This study showed that LAT1 was constitutively expressed in normal crypt base cells, ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 May","modification":"2025-05-18T13:25:52.279Z","creation":"2025-02-19T02:57:11.214Z"},"accession":"S-EPMC10140238","cross_references":{"pubmed":["36739585"],"doi":["10.1007/s00535-023-01960-5"]}}