biostudies-literatureSui YKobe UniversityJapan Society for the Promotion of Science444-457https://www.ebi.ac.uk/biostudies/studies/S-EPMC10140238biostudies-literatureUnknown58(5)<h4>Background</h4>Amino acid transporters play an important role in supplying nutrition to cells and are associated with cell proliferation. L-type amino acid transporter 1 (LAT1) is highly expressed in many types of cancers and promotes tumor growth; however, how LAT1 affects tumor development is not fully understood.<h4>Methods</h4>To investigate the role of LAT1 in intestinal tumorigenesis, mice carrying LAT1 floxed alleles that also expressed Cre recombinase from the promoter of gene encoding Villin were crossed to an Apc^Min/+ background (LAT1^fl/fl; vil-cre; Apc^Min/+), which were subject to analysis; organoids derived from those mice were also analyzed.<h4>Results</h4>This study showed that LAT1 was constitutively expressed in normal crypt base cells, Journal of gastroenterologyLAT1 expression influences Paneth cell number and tumor development in Apc^Min/+ mice.PMC1014023820H0412319K08421Ku YSasaki KKong LKinoshita MYoshida RIto YSui YKotani TShinohara MKanai YTokunaga ETian ZMatozaki TOhgaki RWatanabe DHoshi NKodama YMiyazaki HOkamoto NOoi MZen YfalseLAT1 expression influences Paneth cell number and tumor development in Apc^Min/+ mice.<h4>Background</h4>Amino acid transporters play an important role in supplying nutrition to cells and are associated with cell proliferation. L-type amino acid transporter 1 (LAT1) is highly expressed in many types of cancers and promotes tumor growth; however, how LAT1 affects tumor development is not fully understood.<h4>Methods</h4>To investigate the role of LAT1 in intestinal tumorigenesis, mice carrying LAT1 floxed alleles that also expressed Cre recombinase from the promoter of gene encoding Villin were crossed to an Apc^Min/+ background (LAT1^fl/fl; vil-cre; Apc^Min/+), which were subject to analysis; organoids derived from those mice were also analyzed.<h4>Results</h4>This study showed that LAT1 was constitutively expressed in normal crypt base cells, 2023-01-01T00:00:00Z2023 May2025-05-18T13:25:52.279Z2025-02-19T02:57:11.214ZS-EPMC101402383673958510.1007/s00535-023-01960-5