{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Loh JW"],"funding":["MOH | National Medical Research Council","MOH | National Medical Research Council (NMRC)"],"pagination":["461"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10140281"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6(1)"],"pubmed_abstract":["Angiosarcomas are rare malignant tumors of the endothelium, arising commonly from the head and neck region (AS-HN) and recently associated with ultraviolet (UV) exposure and human herpesvirus-7 infection. We examined 81 cases of angiosarcomas, including 47 cases of AS-HN, integrating information from whole genome sequencing, gene expression profiling and spatial transcriptomics (10X Visium). In the AS-HN cohort, we observed recurrent somatic mutations in CSMD3 (18%), LRP1B (18%), MUC16 (18%), POT1 (16%) and TP53 (16%). UV-positive AS-HN harbored significantly higher tumor mutation burden than UV-negative cases (p = 0.0294). NanoString profiling identified three clusters with distinct tumor inflammation signature scores (p < 0.001). Spatial transcriptomics revealed topological profiles of t"],"journal":["Communications biology"],"pubmed_title":["Spatial transcriptomics reveal topological immune landscapes of Asian head and neck angiosarcoma."],"pmcid":["PMC10140281"],"funding_grant_id":["NMRC/STAR/0006/2009","TA21jun-0005","CG21APR200","SEEDFD21jun-0002"],"pubmed_authors":["Kannan B","Ko TK","Gu NX","Ong CK","Lee JY","Guan P","Lim BY","Teh BT","Loh JW","Yeong J","Lee ECY","Ng CC","Lim JCT","Lim JQ","Lim AH","Chan JY"],"additional_accession":[]},"is_claimable":false,"name":"Spatial transcriptomics reveal topological immune landscapes of Asian head and neck angiosarcoma.","description":"Angiosarcomas are rare malignant tumors of the endothelium, arising commonly from the head and neck region (AS-HN) and recently associated with ultraviolet (UV) exposure and human herpesvirus-7 infection. We examined 81 cases of angiosarcomas, including 47 cases of AS-HN, integrating information from whole genome sequencing, gene expression profiling and spatial transcriptomics (10X Visium). In the AS-HN cohort, we observed recurrent somatic mutations in CSMD3 (18%), LRP1B (18%), MUC16 (18%), POT1 (16%) and TP53 (16%). UV-positive AS-HN harbored significantly higher tumor mutation burden than UV-negative cases (p = 0.0294). NanoString profiling identified three clusters with distinct tumor inflammation signature scores (p < 0.001). Spatial transcriptomics revealed topological profiles of t","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2025-04-26T01:28:42.045Z","creation":"2025-04-06T10:04:49.339Z"},"accession":"S-EPMC10140281","cross_references":{"pubmed":["37106027"],"doi":["10.1038/s42003-023-04856-5"]}}