biostudies-literatureTian YNational Natural Science Foundation of ChinaHubei Provincial Natural Science Foundation of China3341https://www.ebi.ac.uk/biostudies/studies/S-EPMC10140953biostudies-literatureUnknown28(8)A highly regioselective reaction of 2-indolylmethanols with enamides has been developed at room temperature by using AlCl₃ as a catalyst. A wide range of hybrids (40 examples) of indoles and enamides were obtained in moderate to good yields (up to 98% yield). This transformation represents the efficient way to introduce biologically important indoles and enamides skeleton into structurally complex hybrids.Molecules (Basel, Switzerland)Regioselective Reaction of 2-Indolylmethanols with Enamides.PMC1014095381973208, 521732792019CFB624Liu XZou YLiang EZheng YHe DWang QTian YGao LfalseRegioselective Reaction of 2-Indolylmethanols with Enamides.A highly regioselective reaction of 2-indolylmethanols with enamides has been developed at room temperature by using AlCl₃ as a catalyst. A wide range of hybrids (40 examples) of indoles and enamides were obtained in moderate to good yields (up to 98% yield). This transformation represents the efficient way to introduce biologically important indoles and enamides skeleton into structurally complex hybrids.2023-01-01T00:00:00Z2023 Apr2025-05-18T13:25:56.911Z2024-10-18T18:32:18.136ZS-EPMC101409533711057610.3390/molecules28083341