biostudies-literatureUnknownJiang S<h4>Importance</h4>Although breast density is an established risk factor for breast cancer, longitudinal changes in breast density have not been extensively studied to determine whether this factor is associated with breast cancer risk.<h4>Objective</h4>To prospectively evaluate the association between change in mammographic density in each breast over time and risk of subsequent breast cancer.<h4>Design, setting, and participants</h4>This nested case-control cohort study was sampled from the Joanne Knight Breast Health Cohort of 10 481 women free from cancer at entry and observed from November 3, 2008, to October 31, 2020, with routine screening mammograms every 1 to 2 years, providing a measure of breast density. Breast cancer screening was provided for a diverse population of women in tJAMA oncologyhttps://www.ebi.ac.uk/biostudies/studies/S-EPMC10141289biostudies-literatureLongitudinal Analysis of Change in Mammographic Density in Each Breast and Its Association With Breast Cancer Risk.PMC10141289Colditz GABennett DLRosner BAJiang SfalseLongitudinal Analysis of Change in Mammographic Density in Each Breast and Its Association With Breast Cancer Risk.<h4>Importance</h4>Although breast density is an established risk factor for breast cancer, longitudinal changes in breast density have not been extensively studied to determine whether this factor is associated with breast cancer risk.<h4>Objective</h4>To prospectively evaluate the association between change in mammographic density in each breast over time and risk of subsequent breast cancer.<h4>Design, setting, and participants</h4>This nested case-control cohort study was sampled from the Joanne Knight Breast Health Cohort of 10 481 women free from cancer at entry and observed from November 3, 2008, to October 31, 2020, with routine screening mammograms every 1 to 2 years, providing a measure of breast density. Breast cancer screening was provided for a diverse population of women in t2023-01-01T00:00:00Z2023 Apr2025-05-29T19:45:06.156Z2025-04-06T10:02:24.668ZS-EPMC101412893710392210.1001/jamaoncol.2023.0434