{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["23"],"submitter":["Nagayasu-Tanaka T"],"pubmed_abstract":["<h4>Introduction</h4>There has been an increasing desire for the development of predictive periodontal regenerative therapy for severe periodontitis. In this study, we investigated the effect of the combined use of fibroblast growth factor-2 (FGF-2), a drug for periodontal regeneration approved in Japan, and carbonated apatite (CO<sub>3</sub>Ap), bioresorbable and osteoconductive scaffold, on periodontal regeneration in beagle dog model of one-wall periodontal defect (severe intraosseous defect) for 24 weeks in comparison with CO<sub>3</sub>Ap or vehicle alone.<h4>Methods</h4>One-wall periodontal defects were created (mesiodistal width × depth: 4 × 4 mm) on the mesial portion of the mandibular first molar (M1) of beagle dogs on both side. Mixture of FGF-2 and CO<sub>3</sub>Ap, vehicle and "],"journal":["Regenerative therapy"],"pagination":["84-93"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10141504"],"repository":["biostudies-literature"],"pubmed_title":["Effects of combined application of fibroblast growth factor (FGF)-2 and carbonate apatite for tissue regeneration in a beagle dog model of one-wall periodontal defect."],"pmcid":["PMC10141504"],"pubmed_authors":["Anzai J","Takedachi M","Harada T","Nagayasu-Tanaka T","Murakami S","Kitamura M"],"additional_accession":[]},"is_claimable":false,"name":"Effects of combined application of fibroblast growth factor (FGF)-2 and carbonate apatite for tissue regeneration in a beagle dog model of one-wall periodontal defect.","description":"<h4>Introduction</h4>There has been an increasing desire for the development of predictive periodontal regenerative therapy for severe periodontitis. In this study, we investigated the effect of the combined use of fibroblast growth factor-2 (FGF-2), a drug for periodontal regeneration approved in Japan, and carbonated apatite (CO<sub>3</sub>Ap), bioresorbable and osteoconductive scaffold, on periodontal regeneration in beagle dog model of one-wall periodontal defect (severe intraosseous defect) for 24 weeks in comparison with CO<sub>3</sub>Ap or vehicle alone.<h4>Methods</h4>One-wall periodontal defects were created (mesiodistal width × depth: 4 × 4 mm) on the mesial portion of the mandibular first molar (M1) of beagle dogs on both side. Mixture of FGF-2 and CO<sub>3</sub>Ap, vehicle and ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jun","modification":"2025-04-04T20:50:37.044Z","creation":"2025-04-04T20:50:37.044Z"},"accession":"S-EPMC10141504","cross_references":{"pubmed":["37122358"],"doi":["10.1016/j.reth.2023.04.002"]}}