{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Suarez Carantona C"],"funding":["Ministry of Health"],"pagination":["2965"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10141633"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(8)"],"pubmed_abstract":["<h4>Objective</h4>We aimed to test the non-inferiority of oral versus intravenous hydration in the incidence of contrast-associated acute kidney injury (CA-AKI) in elderly outpatients undergoing a contrast-enhanced computed tomography (CE-CT) scan.<h4>Methods</h4>PNIC-Na (NCT03476460) is a phase-2, single-center, randomized, open-label, non-inferiority trial. We included outpatients undergoing a CE-CT scan, >65 years having at least one risk factor for CA-AKI, such as diabetes, heart failure, or an estimated glomerular filtration rate (eGFR) of 30-59 mL/min/1.73 m². Participants were randomized (1:1) to oral sodium-chloride capsules or intravenous hydration. The primary outcome was an increase in serum creatinine >0.3 mg/dL or a reduction in eGFR >25% within 48 h. The non-inferiority margi"],"journal":["Journal of clinical medicine"],"pubmed_title":["Oral Sodium Chloride in the Prevention of Contrast-Associated Acute Kidney Injury in Elderly Outpatients: The PNIC-Na Randomized Non-Inferiority Trial."],"pmcid":["PMC10141633"],"funding_grant_id":["EC11-132; 2012/0019"],"pubmed_authors":["Manzano L","Olavarria Delgado A","Suarez Carantona C","Lopez Castellanos G","Gomez Del Olmo V","Moralejo Martin M","Fabregate M","Ruiz Ortega RA","Blazquez Sanchez J","Lopez Rodriguez M","Pumares Alvarez MB","Bara Ledesma N","Sanchez Gallego MC","Soto Perez-Olivares J","Liano F","Llacer P","Escobar Cervantes C"],"additional_accession":[]},"is_claimable":false,"name":"Oral Sodium Chloride in the Prevention of Contrast-Associated Acute Kidney Injury in Elderly Outpatients: The PNIC-Na Randomized Non-Inferiority Trial.","description":"<h4>Objective</h4>We aimed to test the non-inferiority of oral versus intravenous hydration in the incidence of contrast-associated acute kidney injury (CA-AKI) in elderly outpatients undergoing a contrast-enhanced computed tomography (CE-CT) scan.<h4>Methods</h4>PNIC-Na (NCT03476460) is a phase-2, single-center, randomized, open-label, non-inferiority trial. We included outpatients undergoing a CE-CT scan, >65 years having at least one risk factor for CA-AKI, such as diabetes, heart failure, or an estimated glomerular filtration rate (eGFR) of 30-59 mL/min/1.73 m². Participants were randomized (1:1) to oral sodium-chloride capsules or intravenous hydration. The primary outcome was an increase in serum creatinine >0.3 mg/dL or a reduction in eGFR >25% within 48 h. The non-inferiority margi","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2025-04-19T17:17:18.737Z","creation":"2024-11-20T00:52:26.847Z"},"accession":"S-EPMC10141633","cross_references":{"pubmed":["37109303"],"doi":["10.3390/jcm12082965"]}}