biostudies-literatureSuarez Carantona CMinistry of Health2965https://www.ebi.ac.uk/biostudies/studies/S-EPMC10141633biostudies-literatureUnknown12(8)<h4>Objective</h4>We aimed to test the non-inferiority of oral versus intravenous hydration in the incidence of contrast-associated acute kidney injury (CA-AKI) in elderly outpatients undergoing a contrast-enhanced computed tomography (CE-CT) scan.<h4>Methods</h4>PNIC-Na (NCT03476460) is a phase-2, single-center, randomized, open-label, non-inferiority trial. We included outpatients undergoing a CE-CT scan, >65 years having at least one risk factor for CA-AKI, such as diabetes, heart failure, or an estimated glomerular filtration rate (eGFR) of 30-59 mL/min/1.73 m². Participants were randomized (1:1) to oral sodium-chloride capsules or intravenous hydration. The primary outcome was an increase in serum creatinine >0.3 mg/dL or a reduction in eGFR >25% within 48 h. The non-inferiority margiJournal of clinical medicineOral Sodium Chloride in the Prevention of Contrast-Associated Acute Kidney Injury in Elderly Outpatients: The PNIC-Na Randomized Non-Inferiority Trial.PMC10141633EC11-132; 2012/0019Manzano LOlavarria Delgado ASuarez Carantona CLopez Castellanos GGomez Del Olmo VMoralejo Martin MFabregate MRuiz Ortega RABlazquez Sanchez JLopez Rodriguez MPumares Alvarez MBBara Ledesma NSanchez Gallego MCSoto Perez-Olivares JLiano FLlacer PEscobar Cervantes CfalseOral Sodium Chloride in the Prevention of Contrast-Associated Acute Kidney Injury in Elderly Outpatients: The PNIC-Na Randomized Non-Inferiority Trial.<h4>Objective</h4>We aimed to test the non-inferiority of oral versus intravenous hydration in the incidence of contrast-associated acute kidney injury (CA-AKI) in elderly outpatients undergoing a contrast-enhanced computed tomography (CE-CT) scan.<h4>Methods</h4>PNIC-Na (NCT03476460) is a phase-2, single-center, randomized, open-label, non-inferiority trial. We included outpatients undergoing a CE-CT scan, >65 years having at least one risk factor for CA-AKI, such as diabetes, heart failure, or an estimated glomerular filtration rate (eGFR) of 30-59 mL/min/1.73 m². Participants were randomized (1:1) to oral sodium-chloride capsules or intravenous hydration. The primary outcome was an increase in serum creatinine >0.3 mg/dL or a reduction in eGFR >25% within 48 h. The non-inferiority margi2023-01-01T00:00:00Z2023 Apr2025-04-19T17:17:18.737Z2024-11-20T00:52:26.847ZS-EPMC101416333710930310.3390/jcm12082965