{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhao P"],"funding":["National Natural Science Foundation of China"],"pagination":["3389"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10142363"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["28(8)"],"pubmed_abstract":["Triple-negative breast cancer (TNBC) is the most aggressive molecular subtype of breast cancer. Curcumol, as a natural small molecule compound, has potential anti-breast cancer activity. In this study, we chemically synthesized a derivative of curcumol, named HCL-23, by structural modification and explored its effect on and underlying mechanism regarding TNBC progression. MTT and colony formation assays demonstrated that HCL-23 significantly inhibited TNBC cells proliferation. HCL-23 induced G2/M phase cell cycle arrest and repressed the capability of migration, invasion, and adhesion in MDA-MB-231 cells. RNA-seq results identified 990 differentially expressed genes including 366 upregulated and 624 downregulated genes. Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), an"],"journal":["Molecules (Basel, Switzerland)"],"pubmed_title":["A Novel Derivative of Curcumol, HCL-23, Inhibits the Malignant Phenotype of Triple-Negative Breast Cancer and Induces Apoptosis and HO-1-Dependent Ferroptosis."],"pmcid":["PMC10142363"],"funding_grant_id":["82160813, 32060210, 81872772, 81960546, U1812403"],"pubmed_authors":["Qiu J","Yang J","Pan Y","Chen M","Chen L","Hao X","Huang L","Song H","Gao F","Li Y","Pan C","Zhao P","Jin J","Tang Y"],"additional_accession":[]},"is_claimable":false,"name":"A Novel Derivative of Curcumol, HCL-23, Inhibits the Malignant Phenotype of Triple-Negative Breast Cancer and Induces Apoptosis and HO-1-Dependent Ferroptosis.","description":"Triple-negative breast cancer (TNBC) is the most aggressive molecular subtype of breast cancer. Curcumol, as a natural small molecule compound, has potential anti-breast cancer activity. In this study, we chemically synthesized a derivative of curcumol, named HCL-23, by structural modification and explored its effect on and underlying mechanism regarding TNBC progression. MTT and colony formation assays demonstrated that HCL-23 significantly inhibited TNBC cells proliferation. HCL-23 induced G2/M phase cell cycle arrest and repressed the capability of migration, invasion, and adhesion in MDA-MB-231 cells. RNA-seq results identified 990 differentially expressed genes including 366 upregulated and 624 downregulated genes. Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), an","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2025-04-25T21:20:11.349Z","creation":"2024-12-04T10:48:54.513Z"},"accession":"S-EPMC10142363","cross_references":{"pubmed":["37110625"],"doi":["10.3390/molecules28083389"]}}