biostudies-literatureHajikarimlou MNatural Sciences and Engineering Research Council445https://www.ebi.ac.uk/biostudies/studies/S-EPMC10143089biostudies-literatureUnknown9(4)Mitochondria possess their own DNA (mtDNA) and are capable of carrying out their transcription and translation. Although protein synthesis can take place in mitochondria, the majority of the proteins in mitochondria have nuclear origin. 3' and 5' untranslated regions of mRNAs (3'-UTR and 5'-UTR, respectively) are thought to play key roles in directing and regulating the activity of mitochondria mRNAs. Here we investigate the association between the presence of 3'-UTR from <i>OXA1</i> gene on a prokaryotic reporter mRNA and mitochondrial translation in yeast. <i>OXA1</i> is a nuclear gene that codes for mitochondrial inner membrane insertion protein and its 3'-UTR is shown to direct its mRNA toward mitochondria. It is not clear, however, if this mRNA may also be translated by mitochondria. Journal of fungi (Basel, Switzerland)A Correlation between 3'-UTR of <i>OXA1</i> Gene and Yeast Mitochondrial Translation.PMC10143089123456Sunba NSmith MNazemof NHolcik MSamanfar BMoutaoufik MTPhanse SBabu MHajikarimlou MHooshyar MGolshani ASaid KBfalseA Correlation between 3'-UTR of <i>OXA1</i> Gene and Yeast Mitochondrial Translation.Mitochondria possess their own DNA (mtDNA) and are capable of carrying out their transcription and translation. Although protein synthesis can take place in mitochondria, the majority of the proteins in mitochondria have nuclear origin. 3' and 5' untranslated regions of mRNAs (3'-UTR and 5'-UTR, respectively) are thought to play key roles in directing and regulating the activity of mitochondria mRNAs. Here we investigate the association between the presence of 3'-UTR from <i>OXA1</i> gene on a prokaryotic reporter mRNA and mitochondrial translation in yeast. <i>OXA1</i> is a nuclear gene that codes for mitochondrial inner membrane insertion protein and its 3'-UTR is shown to direct its mRNA toward mitochondria. It is not clear, however, if this mRNA may also be translated by mitochondria. 2023-01-01T00:00:00Z2023 Apr2025-04-04T19:19:20.882Z2025-04-04T19:19:20.882ZS-EPMC101430893710890010.3390/jof9040445