{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Nandi A"],"funding":["Indian Veterinary Research Institute","Indian Council of Agricultural Research"],"pagination":["881"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10143353"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(4)"],"pubmed_abstract":["<i>Hyalomma anatolicum</i> is the principal vector for <i>Theileria annulata</i>, <i>T. equi</i>, and <i>T. Lestoquardi</i> in animals and the Crimean-Congo hemorrhagic fever virus in humans. Due to the gradual loss of efficacy of the available acaricides against field tick populations, the development of phytoacaricides and vaccines has been considered the two most critical components of the integrated tick management strategies. In the present study, in order to induce both cellular and humoral immune responses in the host against <i>H. anatolicum</i>, two multi-epitopic peptides (MEPs), i.e., VT1 and VT2, were designed. The immune-stimulating potential of the constructs was determined by in silicoinvestigation on allergenicity (non-allergen, antigenic (0.46 and 1.0046)), physicochemical"],"journal":["Vaccines"],"pubmed_title":["Protective Efficacy of Multiple Epitope-Based Vaccine against <i>Hyalomma anatolicum</i>, Vector of <i>Theileria annulata</i> and Crimean-Congo Hemorrhagic Fever Virus."],"pmcid":["PMC10143353"],"funding_grant_id":["NASF/ABA-6015/2016-17/357"],"pubmed_authors":["Shrivastava S","Tiwari V","Ghosh S","Saini M","Bhure SK","Nandi A","Manisha","Solanki V","Sankar M","Sajjanar B"],"additional_accession":[]},"is_claimable":false,"name":"Protective Efficacy of Multiple Epitope-Based Vaccine against <i>Hyalomma anatolicum</i>, Vector of <i>Theileria annulata</i> and Crimean-Congo Hemorrhagic Fever Virus.","description":"<i>Hyalomma anatolicum</i> is the principal vector for <i>Theileria annulata</i>, <i>T. equi</i>, and <i>T. Lestoquardi</i> in animals and the Crimean-Congo hemorrhagic fever virus in humans. Due to the gradual loss of efficacy of the available acaricides against field tick populations, the development of phytoacaricides and vaccines has been considered the two most critical components of the integrated tick management strategies. In the present study, in order to induce both cellular and humoral immune responses in the host against <i>H. anatolicum</i>, two multi-epitopic peptides (MEPs), i.e., VT1 and VT2, were designed. The immune-stimulating potential of the constructs was determined by in silicoinvestigation on allergenicity (non-allergen, antigenic (0.46 and 1.0046)), physicochemical","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2026-06-27T03:21:03.52Z","creation":"2024-11-09T20:47:33.789Z"},"accession":"S-EPMC10143353","cross_references":{"pubmed":["37112793"],"doi":["10.3390/vaccines11040881"]}}