{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Blaudszun AR"],"funding":["National Research Foundation (NRF)"],"pagination":["1295"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10143374"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(4)"],"pubmed_abstract":["Adoptive cell transfer (ACT) has shown remarkable therapeutic efficacy against blood cancers such as leukemia and lymphomas, but its effect is still limited due to the lack of well-defined antigens expressed by aberrant cells within tumors, the insufficient trafficking of administered T cells to the tumor sites, as well as immunosuppression induced by the tumor microenvironment (TME). In this study, we propose the adoptive transfer of photosensitizer (PS)-loaded cytotoxic T cells for a combinational photodynamic and cancer immunotherapy. Temoporfin (Foscan<sup>®</sup>), a clinically applicable porphyrin derivative, was loaded into OT-1 cells (PS-OT-1 cells). The PS-OT-1 cells efficiently produced a large amount of reactive oxygen species (ROS) under visible light irradiation in a culture; "],"journal":["Pharmaceutics"],"pubmed_title":["Adoptive Transfer of Photosensitizer-Loaded Cytotoxic T Cells for Combinational Photodynamic Therapy and Cancer Immuno-Therapy."],"pmcid":["PMC10143374"],"funding_grant_id":["NRF-2022M3H4A1A03067401 and 2021R1C1C2005460"],"pubmed_authors":["Kim WJ","Shim MK","Um W","Kim K","Blaudszun AR","Yoon HY"],"additional_accession":[]},"is_claimable":false,"name":"Adoptive Transfer of Photosensitizer-Loaded Cytotoxic T Cells for Combinational Photodynamic Therapy and Cancer Immuno-Therapy.","description":"Adoptive cell transfer (ACT) has shown remarkable therapeutic efficacy against blood cancers such as leukemia and lymphomas, but its effect is still limited due to the lack of well-defined antigens expressed by aberrant cells within tumors, the insufficient trafficking of administered T cells to the tumor sites, as well as immunosuppression induced by the tumor microenvironment (TME). In this study, we propose the adoptive transfer of photosensitizer (PS)-loaded cytotoxic T cells for a combinational photodynamic and cancer immunotherapy. Temoporfin (Foscan<sup>®</sup>), a clinically applicable porphyrin derivative, was loaded into OT-1 cells (PS-OT-1 cells). The PS-OT-1 cells efficiently produced a large amount of reactive oxygen species (ROS) under visible light irradiation in a culture; ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2025-04-21T17:25:33.927Z","creation":"2025-04-05T16:40:45.471Z"},"accession":"S-EPMC10143374","cross_references":{"pubmed":["37111779"],"doi":["10.3390/pharmaceutics15041295"]}}